PMID: 2504442May 1, 1989

Patterns of convulsive susceptibility in the long-sleep and short-sleep selected mouse lines

Brain Research Bulletin
T D McIntyre, H P Alpern

Abstract

It has been hypothesized that the Long-Sleep and Short-Sleep mouse lines were bidirectionally selected for high and low brain excitability, and further, that these differences are mediated by the benzodiazepine/gamma-aminobutyric acid (GABA) receptor-chloride channel complex. Hence, mice from both lines were administered seven convulsants (bicuculline, pentylenetetrazol, 3-carbomethoxy-beta-carboline, picrotoxin, caffeine, flurothyl and strychnine) and myoclonic and clonic seizure latencies recorded. Supporting the original hypothesis, the results show that the two lines were differentiated by all of the convulsants and that in response to the drugs, three distinct convulsive patterns were found. Nevertheless, a simple genetic model accounting for these results was not evident. To further clarify these susceptibility patterns, a convulsant representing each of these patterns (bicuculline, pentylenetetrazol or caffeine) was administered in conjunction with the anticonvulsant-barbiturate phenobarbital or the benzodiazepine antagonist Ro 15-1788. Irrespective of the convulsant given, phenobarbital attenuated both myoclonus and clonus subsequent to all convulsants, while Ro 15-1788 had a more discrete anticonvulsant profile.

References

Jan 1, 1976·British Journal of Pharmacology·R G HillD W Straughan
Jan 1, 1986·Psychopharmacology·S E File, S Pellow
Aug 1, 1986·Pharmacology, Biochemistry, and Behavior·H P Alpern, T D McIntyre
Feb 1, 1987·Journal of Clinical Psychopharmacology·D J Greenblatt, R I Shader
Jun 1, 1985·Pediatrics·S M DonnG W Goldstein
Jun 29, 1971·Experimental Brain Research·D R CurtisG A Johnston
Mar 1, 1969·International Journal of Neuropharmacology·R A DavidoffR Werman
Jan 18, 1980·Science·J F TallmanD W Gallager
Jan 1, 1982·Annual Review of Pharmacology and Toxicology·R W Olsen
Jan 1, 1982·Psychopharmacology·E P BonettiW Haefely
Jan 1, 1981·Psychopharmacology·P J MarangosP Skolnick
Apr 22, 1983·European Journal of Pharmacology·A MartzR A Harris
Jan 1, 1981·British Journal of Anaesthesia·D D Koblin, J E Deady

Related Concepts

Anticonvulsants
Bicuculline
Convulsant Effect
Romazicon
Pentazol
Luminal
Reaction Time
Non-epileptic Convulsion
Sleep, Slow-Wave

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