Patterns of cytokine secretion in murine leishmaniasis: correlation with disease progression or resolution.

Infection and Immunity
W H BoomR G Titus

Abstract

Susceptibility or resistance to infection with Leishmania major correlates with the ability of mice to produce characteristic panels of lymphokines in response to the parasite. To investigate the role of antigen-presenting cells in this phenomenon, we developed a model system which used congenic (H-2d) susceptible and resistant mice. L. major-specific T cells were isolated from infected BALB/c and B10.D2 mice, and the cells were restimulated in vitro on syngenic or congenic antigen-presenting cells. BALB/c L. major-reactive T cells restimulated with either antigen-presenting cell produced high levels of interleukin-4 and low levels of gamma interferon. In contrast, T cells from B10.D2 mice produced gamma interferon. Radiation-induced chimeras reconstituted with BALB/c bone marrow also produced more interleukin-4 in response to L. major than did chimeras reconstituted with B10.D2 bone marrow. To test whether this pattern of cytokine secretion was unique to infection with L. major, we infected the mice with a second intracellular pathogen, Mycobacterium bovis BCG. Mycobacterium-specific T cells from both BALB/c and B10.D2 mice produced interleukin-2 and no interleukin-4. Finally, when BALB/c mice were vaccinated with avirulent L....Continue Reading

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Citations

Jun 1, 1993·Immunological Reviews·M J DallmanH M Charlton
Feb 5, 1999·European Journal of Immunology·D PiedrafitaF Y Liew
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Jan 1, 1992·Progress in Growth Factor Research·D RennickG Holland
May 28, 2011·International Immunopharmacology·Rajeev Nagill, Sukhbir Kaur

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