Patterns of DNA sequence variation suggest the recent action of positive selection in the janus-ocnus region of Drosophila simulans.

Genetics
John ParschD L Hartl

Abstract

Levels of nucleotide polymorphism in three paralogous Drosophila simulans genes, janusA (janA), janusB (janB), and ocnus (ocn), were surveyed by DNA sequencing. The three genes lie in tandem within a 2.5-kb region of chromosome arm 3R. In a sample of eight alleles from a worldwide distribution we found a significant departure from neutrality by several statistical tests. The most striking feature of this sample was that in a 1.7-kb region containing the janA and janB genes, 30 out of 31 segregating sites contained variants present only once in the sample, and 29 of these unique variants were found in the same allele. A restriction survey of an additional 28 lines of D. simulans revealed strong linkage disequilibrium over the janA-janB region and identified six more alleles matching the rare haplotype. Among the rare alleles, the level of DNA sequence variation was typical for D. simulans autosomal genes and showed no departure from neutrality. In addition, the rare haplotype was more similar to the D. melanogaster sequence, indicating that it was the ancestral form. These results suggest that the derived haplotype has risen to high worldwide frequency relatively recently, most likely as a result of natural selection.

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Citations

Apr 16, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Rama S Singh, Rob J Kulathinal
May 5, 2005·Journal of Molecular Evolution·Michael E SteiperMaryellen Ruvolo
Jul 29, 2004·Genetics·Yuseob Kim, Rasmus Nielsen
Jul 30, 2004·Molecular Biology and Evolution·Zhi ZhangJohn Parsch
Oct 26, 2007·Trends in Genetics : TIG·Jeffrey D JensenCharles F Aquadro
Apr 19, 2006·Current Biology : CB·Philipp KhaitovichSvante Pääbo
Oct 24, 2003·Genetics·Humberto QuesadaMontserrat Aguadé
Mar 20, 2002·Genetics·Molly Przeworski
May 3, 2007·Heredity·K R ThorntonP Andolfatto
Apr 23, 2002·Nature Reviews. Genetics·Kristin G ArdlieMark Seielstad
Jul 27, 2006·Molecular Biology and Evolution·Sascha GlinkaWolfgang Stephan
Oct 28, 2005·Genome Research·Rasmus NielsenCarlos Bustamante

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