Abstract
The effect of gastrointestinal parasitism on patterns of edible tissue depletion of doramectin was studied in greyface Suffolk lambs. Twelve weight-matched pairs of lambs were allocated into group I (nonparasitized, pretreated with three administrations of 5 mg/kg fenbendazole) and group II (parasitized, did not receive anthelmintic treatment). Both groups were maintained together under similar conditions for 70 days, when they were treated with a subcutaneous dose of 0.2 mg/kg bw doramectin. At 7, 14, 21, and 28 days after doramectin administration, three lambs from each group were slaughtered and samples of liver, kidney, muscle, and fat were obtained. Pre-treatment with fenbendazole significantly reduced the nematode fecal egg count and significantly increased lamb body weight compared to the parasitized group. Doramectin was detected in all of the tissues up to 28 days post-treatment. Significantly higher and more persistent doramectin concentrations were found in the nonparasitized lambs compared to the parasitized animals. Considering the EMEA maximum residue limits for doramectin in fat, the calculated withdrawal period for the healthy lambs (43 days) was significantly higher than that for the parasitized animals (26 days).
References
Jan 14, 1978·The Veterinary Record·A R Sykes
Sep 1, 1988·Journal of Veterinary Pharmacology and Therapeutics·J A Bogan, Q A McKellar
May 1, 1986·The British Journal of Nutrition·D P PoppiR L Coop
May 5, 1995·Journal of Chromatography. B, Biomedical Applications·M M AertsU A Brinkman
Jun 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·C E LanusseR K Prichard
Jul 1, 1993·Veterinary Parasitology·S R WicksD G Smith
Apr 1, 1993·Clinical Pharmacology and Therapeutics·P O OkonkwoU Klotz
Aug 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·M A NowakowskiR M Jones
Mar 1, 1997·Veterinary Parasitology·B E StrombergH Hanke
Apr 1, 1997·Journal of Veterinary Pharmacology and Therapeutics·C LanusseM Alvinerie
Aug 1, 1997·Journal of Veterinary Pharmacology and Therapeutics·J M DelmasP Sanders
Feb 14, 1998·Veterinary Parasitology·M T Fox
Mar 20, 1998·The British Journal of Nutrition·R A DynesA R Sykes
Aug 24, 1999·Veterinary Parasitology·R L Coop, I Kyriazakis
Apr 4, 2000·Journal of Veterinary Pharmacology and Therapeutics·A H Atta, M N Abo-Shihada
Dec 7, 2000·Journal of Veterinary Pharmacology and Therapeutics·D R HennessyD Gottschall
Jan 16, 2001·Journal of Agricultural and Food Chemistry·A LifschitzC Lanusse
Jun 21, 2002·Australian Veterinary Journal·P I Veale
May 6, 2004·Parasitology Research·Anne LespineGilles Aumont
Oct 29, 2005·The Veterinary Journal·Rubén PérezMargarita Arboix
Jan 18, 2006·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·R PérezM Alvinerie
Citations
Nov 7, 2009·Research in Veterinary Science·L MorenoC Lanusse
Oct 17, 2009·Journal of Food Protection·Jianzhong ShenShuangyang Ding
Oct 27, 2020·Journal of Veterinary Pharmacology and Therapeutics·Alla VyniarskaJerzy J Jaroszewski