PMID: 6113871Jan 5, 1981Paper

Patterns of endogenous amino acid release from slices of rat and guinea-pig olfactory cortex

Brain Research
G G CollinsG A Probett

Abstract

A study has been made of the effects of depolarizing stimuli on the release of endogenous amino acid neurotransmitter candidates (aspartate, glutamate, GABA and taurine) from in vitro preparations of rat and guinea pig olfactory cortex. Exposure of small cubes of olfactory cortex tissue from either species to potassium chloride (50 mM) was accompanied by a calcium-dependent release of aspartate, glutamate and GABA. A similar release pattern was evoked by protoveratrine A (100 muM) although the release was largely calcium-independent. Neither agent led to increased release of taurine. Electrical stimulation of the excitatory input (lateral olfactory tract) of freshly prepared, synaptically intact olfactory cortex slices of both species induced significant release of aspartate and GABA from the uncut pial surface and of aspartate, GABA and glutamate from the cut surface. Evoked taurine release occurred from both surfaces of rat olfactory cortex slices but no release was detected from guinea pig olfactory cortex slices. These patterns of release were unaffected by changes in stimulus frequency and were mimicked by protoveratrine A (100 muM) applied to one or other surface. Preincubation of slices from rats for 2 led to loss of tis...Continue Reading

References

Nov 1, 1976·The Journal of Physiology·R M Clark, G G Collins
Feb 1, 1978·The Journal of Physiology·H G Pickles, M A Simmonds
Sep 1, 1976·The Journal of Physiology·H G Pickles, M A Simmonds
Mar 11, 1975·Journal of Neurochemistry·J A HarveyM H Aprison
Mar 19, 1976·Brain Research·H F Bradford, C D Richards
Jun 25, 1976·Brain Research·H F Bradford, H K Ward
Aug 16, 1974·Brain Research·J A HarveyD A Brown
Apr 1, 1972·Hoppe-Seyler's Zeitschrift für physiologische Chemie·G Briel, V Neuhoff

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Citations

Mar 1, 1986·Neuropharmacology·G G Collins, L Surtees
Jul 1, 1988·Neuropharmacology·G G Collins, S J Howlett
Jan 1, 1992·Progress in Neurobiology·P Saransaari, S S Oja
Nov 1, 1983·Neuroscience·N Halász, G M Shepherd
Feb 1, 1984·Hearing Research·D M CasparyC L Faingold
Jun 1, 1986·British Journal of Pharmacology·G G Collins, D G Dewhurst
Aug 1, 1987·British Journal of Pharmacology·J Anson, G G Collins
May 1, 1984·Journal of Neurochemistry·D A GodfreyC D Ross
Nov 1, 1981·Journal of Neurochemistry·M Sandberg, I Jacobson
May 1, 1996·Journal of Neurobiology·M T Shipley, M Ennis
Jul 10, 1982·The Journal of Comparative Neurology·F Macrides, S P Schneider

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