PMID: 2417517Jan 1, 1985

Patterns of expression and organization of cytokeratin intermediate filaments

Annals of the New York Academy of Sciences
R A QuinlanW W Franke

Abstract

Cytokeratins are a large multigene family comprising two polypeptide types, i.e. acidic (type I) and basic (type II) ones, which are distinguished on the basis of immunological, peptide mapping, mRNA hybridization, and primary amino acid sequence data. The acidic (type I) cytokeratins can be subdivided into at least two different subtypes on the basis of their carboxy-terminal sequences. Considerable interspecies conservation of sequences exists, even extending to the 3'-non-coding mRNA regions. Different pairs of type I and II cytokeratins show different resistance to dissociation in urea. Sequence differences of the type I cytokeratins containing functional domains may be an explanation of the observed preference of co-expression with certain type II cytokeratins. The distribution of the different type I and II cytokeratins in normal epithelia and in carcinomas is differentiation related and can be used for cell typing and identification. The cell type-specific expression of cytokeratin polypeptides is recognized at both the protein and the mRNA level. The building block of cytokeratin IFs is a heterotypic tetramer, consisting of two type I and two type II polypeptides arranged in pairs of laterally aligned coiled coils. This...Continue Reading

References

Apr 29, 1998·Microscopy Research and Technique·H B Sarnat
Aug 12, 1998·International Journal of Cancer. Journal International Du Cancer·L HeflerC Kainz
Oct 1, 1990·The American Journal of Anatomy·M H SawafN Forest
Dec 1, 1996·Cancer Metastasis Reviews·R G OshimaC Caulín
Jan 1, 1991·Histochemistry·W KuijpersF C Ramaekers
May 1, 1989·Human Genetics·N C PopescuJ A DiPaolo
Jan 1, 1995·Cell and Tissue Research·E ShezenO Abramsky
Jan 1, 1989·Archives of Oto-rhino-laryngology·W Y Chao, C C Huang
Jan 1, 1988·Histochemistry·M KasperU Karsten
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·B F BurnsW R Parks
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·H GustafssonL E Thornell
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·M CintorinoP Leoncini
Jan 1, 1993·International Journal of Clinical & Laboratory Research·P PontissoA Alberti
Aug 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·L Huschtscha, W Bodmer
Jun 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·D OdaG Bourekis
May 8, 2007·Skeletal Radiology·A RigopoulouN A Athanasou
Nov 19, 2004·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Michaela EndresNicole Rotter
Sep 6, 2008·Histochemistry and Cell Biology·Akihiro HosoyaHan-Sung Jung
Apr 13, 2006·Virchows Archiv : an International Journal of Pathology·Natsuko TatsumiTakanori Hattori
Sep 1, 2005·Digestive Diseases and Sciences·Natsuko TatsumiTakanori Hattori
Oct 1, 1989·Cancer Genetics and Cytogenetics·M A VersnelF C Ramaekers
May 1, 1992·Pediatric Neurology·H B Sarnat
May 1, 1994·European Journal of Cancer. Part B, Oral Oncology·P R Morgan, L Su
Aug 5, 2000·Progress in Retinal and Eye Research·L GermainS L Guérin
Oct 1, 1995·Differentiation; Research in Biological Diversity·C ZhangQ Zeng
Mar 11, 1998·Development, Growth & Differentiation·K Sato, S Yasugi
Aug 25, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A GadducciA R Genazzani

Citations

Nov 25, 1979·Journal of Molecular Biology·D C RuegerA Bignami
Jan 1, 1979·Differentiation; Research in Biological Diversity·E SchmidW W Franke
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G S BennettH Holtzer
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W W FrankeK Weber
Nov 25, 1976·Nature·L D Lee, H P Baden
Dec 1, 1976·Journal of Molecular Biology·R D FraserE Suzuki
Dec 15, 1976·Journal of Molecular Biology·P M SteinertS B Zimmerman
May 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T AchtstätterW W Franke
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·G Blobel
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P BannaschW W Franke
Jun 1, 1981·Journal of Muscle Research and Cell Motility·B H Anderton
Jan 1, 1982·Cold Spring Harbor Symposia on Quantitative Biology·F C RamaekersG P Vooijs
Jan 1, 1982·Cold Spring Harbor Symposia on Quantitative Biology·M OsbornK Weber
Jan 1, 1982·Cold Spring Harbor Symposia on Quantitative Biology·P M SteinertR D Goldman
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·N SahyounP Cuatrecasas
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D R RoopS H Yuspa
Jan 1, 1983·Differentiation; Research in Biological Diversity·R MollW W Franke
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·W W FrankeS Winter
Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·G A BlobelI Vogt-Moykopf
Oct 25, 1984·Journal of Molecular Biology·J L JorcanoW W Franke
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E WangR K Liem
Jun 1, 1983·The Journal of Cell Biology·I Blikstad, E Lazarides

Related Concepts

Peptide Mapping
Tonofilaments
Multigene Family
Nucleic Acid Hybridization Procedure
Keratin
Cytokeratin
Cell Differentiation Process
Coils Program
KRT1
Protein Conformation

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.