Patterns of expression of brain-derived neurotrophic factor and tyrosine kinase B mRNAs and distribution and ultrastructural localization of their proteins in the visual pathway of the adult rat

Neuroscience
O AvwenaghaG Campbell

Abstract

We have examined the cellular and subcellular distribution and the patterns of expression of brain-derived neurotrophic factor (BDNF), and of its high affinity receptor, tyrosine kinase B (TrkB), in retinorecipient regions of the brain, including the superior colliculus, the lateral geniculate nucleus and the olivary pretectal nucleus. In the retinorecipient layers of the superior colliculus, BDNF protein and mRNA were present in the cell bodies of a subpopulation of neurons, and BDNF protein was present in the neuropil as punctate or fiber-like structures. In the lateral geniculate nucleus, however, BDNF mRNA was not detected, and BDNF protein was restricted to punctate and fiber-like structures in the neuropil, especially in the most superficial part of the dorsal lateral geniculate nucleus, just below the optic tract. At the ultrastructural level, BDNF protein was localized predominantly to axon terminals containing round synaptic vesicles and pale mitochondria with irregular cristae, which made asymmetric (Gray type I) synaptic specializations (R-boutons). Enucleation of one eye was followed by loss of BDNF immunoreactivity and disappearance of BDNF-positive R-boutons in the contralateral visual centers, confirming the reti...Continue Reading

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Citations

Dec 31, 2003·Molecular and Cellular Neurosciences·Elisabetta MennaLamberto Maffei
Mar 19, 2014·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Claudia GattaLivia D'Angelo
Mar 14, 2012·The Journal of Cell Biology·Sandra DieniYves-Alain Barde
Aug 8, 2009·Progress in Retinal and Eye Research·Andreas BringmannAndreas Reichenbach
Apr 15, 2008·Experimental Eye Research·Seyed M S Ghazi-NouriDavid G Charteris
Jun 17, 2011·Microscopy Research and Technique·Livia D'AngeloCarla Lucini
Jun 25, 2013·Neuropharmacology·Elke EdelmannTanja Brigadski
Jul 31, 2013·PloS One·Ece SelçukArzu Karabay
Jun 4, 2014·Mens Sana Monographs·Callie Joubert
Sep 1, 2018·Indian Journal of Psychiatry·Anindya Das, Urvashi Rautela
Jul 29, 2017·Expert Review of Ophthalmology·B A MysonaK E Bollinger
Oct 15, 2019·Frontiers in Cellular Neuroscience·Ashish BhandariMatthew J Van Hook
Sep 14, 2020·Experimental Eye Research·Yuan-Yuan HeYong-Mei Zhong
Nov 7, 2021·Clinical & Experimental Ophthalmology·Joshua A Chu-TanRiccardo Natoli

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