Patterns of expression of odorant receptor genes in a Chagas disease vector

Insect Biochemistry and Molecular Biology
Jose Manuel Latorre-EstivalisMarcelo Gustavo Lorenzo

Abstract

Rhodnius prolixus is a triatomine bug acting as a relevant vector of Chagas disease for which the genome sequence has been recently made available. Based on this information, a set of olfactory (ORs) and ionotropic receptor (IRs) genes potentially related to olfactory processes was characterized, and the expression patterns along bug development and in different structures potentially involved in promoting chemosensory-mediated behaviors were studied. For this, diverse bioinformatic procedures were used to validate gene models analyzing their structural and functional features and designing specific primers. Evolutionary relationships among R. prolixus olfactory coreceptors (RproOrco, RproIR25a, RproIR8a and RproIR76b) and their orthologues from other insects were shown to have mostly good bootstrap support values in phylogenetic trees. Moreover, antennal expression was confirmed for most genes included in the study. Both ORs and IRs showed antennal expression along the whole development of bugs of this species, with few exceptional receptors showing gradually increasing expression or expression restricted to the antennae of adult bugs. Finally, the expression of most of the selected genes was confirmed in other structures, suc...Continue Reading

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Citations

Oct 1, 2019·The EMBO Journal·Heike Ilona Rösner, Claus Storgaard Sørensen
Sep 19, 2019·Scientific Reports·Zhou ChenNannan Liu
Feb 1, 2020·BMC Genomics·Jose Manuel Latorre-EstivalisMarcelo Gustavo Lorenzo

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