PMID: 1199704Jan 1, 1975Paper

Patterns of free fatty acids, glycerol, D-beta-hydroxybutyrate and insulin in pregnant women and their newborn infants. Effects of a low and a high insulin response to glucose in the mothers

Acta Obstetricia Et Gynecologica Scandinavica
K EdströmR Luft

Abstract

Twenty-eight healthy women, 17 with high and 11 with low insulin response to glucose but with normal glucose tolerance, were followed throughout pregnancy. Plasma FFA, glycerol and D-beta-hydroxybutyrate as well as plasma insulin and glucose in blood were determined before and during a glucose infusion test (GIT) in each trimester and after pregnancy. In 13 infants of high insulin responders (IHR) and 10 infants of low responders (ILR) an intravenous glucose tolerance test (IVGTT) was performed, and the above lipid parameters were studied at birth and during the IVGTT. The low responder group was postulated to consist mainly of prediabetic individuals (8). Their infants have previously been shown to have an increased glucose assimilation rate at IVGTT (12, 13), as has been shown for infants of diabetic mothers. There was little difference between the two groups of mothers except for the insulin levels during the GIT in non-pregnant and early pregnant subjects, which were considerably lower in the low responders. They all had decreased fasting levels of FFA, glycerol, and D-beta-hydroxybutyrate in mid-pregnancy and normal values in late pregnancy. The ILR showed the same changes in FFA and glycerol as the IHR, but their D-beta-h...Continue Reading

Citations

May 8, 2000·Indian Journal of Pediatrics·M AkisüN Kültürsay
Mar 7, 2017·American Journal of Obstetrics and Gynecology·Roberto RomeroAdi L Tarca
Jun 1, 1981·British Journal of Obstetrics and Gynaecology·M StangenbergL Stånge
Sep 1, 1977·British Journal of Sports Medicine·B Davies, A Daggett

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