Patterns of Fundus Autofluorescence Lifetimes In Eyes of Individuals With Nonexudative Age-Related Macular Degeneration

Investigative Ophthalmology & Visual Science
Lydia SauerPaul S Bernstein

Abstract

To investigate fundus autofluorescence (FAF) lifetimes in patients with nonexudative AMD. A total of 150 eyes of 110 patients (mean age: 73.2 ± 10.7 years) with nonexudative AMD, as well as a healthy group of 57 eyes in 38 subjects (mean age: 66.5 ± 8.7 years), were included. Investigations were conducted at the University Eye Clinic in Jena, Germany, as well as the Moran Eye Center in Salt Lake City, Utah, USA, using the Heidelberg Engineering Spectralis-based fluorescence lifetime imaging ophthalmoscope (FLIO). A 30° retinal field centered at the fovea was investigated. FAF decays were detected in short (498-560 nm) and long (560-720 nm, LSC) spectral channels. The mean fluorescence lifetimes (τm) were calculated. Optical coherence tomography scans and fundus photographs were also recorded. In patients with nonexudative AMD, FLIO shows a ring-shaped pattern of prolonged τm in the LSC. This pattern occurs in all patients with AMD (including very early stages) and in one-third of the healthy controls. FAF lifetimes were longer with more advanced stages. The presence of drusen is associated with prolonged τm when compared with the healthy fundus, but drusen identification is difficult with FLIO only. FLIO detects a clear pattern...Continue Reading

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Jul 20, 2018·Investigative Ophthalmology & Visual Science·Lydia SauerPaul S Bernstein

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Citations

Jun 28, 2018·Translational Vision Science & Technology·Karl M AndersenPaul S Bernstein
Jul 20, 2018·Investigative Ophthalmology & Visual Science·Lydia SauerPaul S Bernstein
Sep 6, 2018·Journal of Biomedical Optics·Lydia SauerMartin Hammer
Mar 14, 2020·Current Opinion in Ophthalmology·Daniel Q Li, Netan Choudhry
May 23, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Marina A YakovlevaMikhail A Ostrovsky
Jul 30, 2019·Retina·Cecinio C RonquilloPaul S Bernstein
Sep 21, 2020·The British Journal of Ophthalmology·Alan Bird
Sep 9, 2020·Investigative Ophthalmology & Visual Science·Rowena SchultzMartin Hammer
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Mar 21, 2019·Biomedical Optics Express·Matthias KlemmJens Haueisen
Dec 21, 2020·Acta Ophthalmologica·Rowena SchultzMartin Hammer
Oct 17, 2020·Translational Vision Science & Technology·Alexandra S VitalePaul S Bernstein
Aug 8, 2020·Progress in Retinal and Eye Research·Steffen Schmitz-ValckenbergFrank G Holz
May 19, 2021·European Journal of Ophthalmology·Ioannis-Nikolaos ChalkiasMagda Tsolaki
Jun 11, 2021·Translational Vision Science & Technology·Lukas GoerdtPaul S Bernstein

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

FLIMX
SPSS
SPCImage

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