Patterns of hepatitis B infection in Egyptian children in the era of obligatory hepatitis B vaccination

Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology
Mona S El-RazikyHanaa M El-Karaksy

Abstract

Mass compulsory HBV vaccination was applied in Egypt in 1992. The first dose of vaccine is administered at 2 months of age and routine screening of pregnant women for HBsAg is not applied. We aimed to evaluate the pattern of HBV infections after the implementation of HBV vaccination in Egyptian children. Fifty-six children with HBV infection presented to the Paediatric Hepatology Unit, Cairo University Children's Hospital, over the period from 1992 to 2006. Their data were reviewed for risk factors, clinical, serological and histopathological profiles. These cases were followed-up for 6.3 ± 3.4 years. The data of those born before 1993 (did not receive HBV vaccine) (group I) was compared to those who received the vaccine (group II). Sixty percent of HBV infected cases were born before 1993. Comparison of data of both groups revealed: (1) A significant younger age of onset in group II (3.34 ± 3.31 years vs. 9.84 + 2.95 years; p ≤ 0.01). (2) Vertical transmission was a significant risk factor in group II. (3) Chronic hepatitis developed in almost half of cases in both groups but cirrhosis was diagnosed only in 4 cases (all from group I) (p=0.04). Vertically transmitted HBV infection is becoming an important risk factor for acquis...Continue Reading

References

Feb 1, 1986·The Journal of Pediatrics·F BortolottiG Realdi
May 31, 2002·The New England Journal of Medicine·Anna S F Lok
Jun 7, 2006·Epidemiologic Reviews·Colin W ShepardBeth P Bell
Nov 6, 2007·Clinics in Liver Disease·Maya Gambarin-Gelwan
Oct 14, 2008·Vaccine·Alessandro R ZanettiDaniel Shouval

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Citations

Jul 4, 2013·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Gasim Ibrahim Gasim
Oct 27, 2018·Acta Paediatrica·Mona El-Said El-RazikyHanaa Mostafa El-Karaksy
Nov 28, 2018·Journal of Ophthalmic & Vision Research·Shahram SamieeMarzieh Sadat Hashemi

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