Patterns of high-dose morphine use in a home-care hospice service: should we be afraid of it?

Cancer
Michaela Bercovitch, Abraham Adunsky

Abstract

Management of cancer pain is one of the most important goals of palliative care. Relieving pain is often problematic. High doses of morphine at home may be required to relieve patients' pain, and is therefore feared. The goals of the current study were to assess the feasibility of high-dose morphine use at home, to characterize the patients, and to examine whether the use of high-dose morphine might affect their survival. The authors retrospectively studied the medical charts of 661 outpatients, which were completed by a home-care hospice team. The authors collected data regarding demographic parameters, medical diagnosis, pain type, morphine dosage, use of rescue doses in addition to regular doses, use of coanalgesics and adjuvant treatments, and survival time as associated with morphine dosage. The authors also compared the data of patients receiving high-dose morphine with those of a group of patients receiving regular doses. The authors identified 435 patients (65.8%) who received morphine for pain relief. Of these, 396 patients (91%) received a dose of 5-299 mg of morphine per day), 32 patients (7.4%) received 300-599 mg of morphine per day), and 7 patients (1.6%) received very high doses (> or = 600 mg of morphine per day...Continue Reading

References

Sep 1, 1990·BMJ : British Medical Journal·J TownsendM Piper
Jul 1, 1995·Journal of Pain and Symptom Management·E BrueraM Suarez-Almazor
Mar 1, 1993·Pain·S E WardD E Weissman
Apr 24, 1993·Lancet·M Zenz, A Willweber-Strumpf
Jul 18, 1996·The New England Journal of Medicine·N A Christakis, J J Escarce
Mar 1, 1996·Journal of Clinical Anesthesia·L RadbruchA Bischoff
Apr 1, 1997·Journal of Pain and Symptom Management·S MercadanteA Agnello
Jul 4, 2001·Drugs·C Ripamonti, E D Dickerson
Jul 17, 2001·Journal of the American Geriatrics Society·W T GalloE H Bradley

❮ Previous
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Citations

Jul 5, 2012·Der Anaesthesist·S Roggendorf, W U Eckart
Feb 13, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sebastiano MercadanteAlessandra Casuccio
May 15, 2007·The New England Journal of Medicine·Agnes van der HeideGerrit van der Wal
Jan 20, 2011·Journal of Palliative Medicine·Samy A AlsirafyNahla A Aklan
Mar 14, 2013·Journal of Palliative Medicine·Scott A IrwinFrank D Ferris
Jul 31, 2008·Critical Care Medicine·Mette L Rurup, Bregje D Onwuteaka-Philipsen
Mar 18, 2006·BMJ : British Medical Journal·Dawn E Davies
Jun 3, 2011·Indian Journal of Palliative Care·Joris GielenBert Broeckaert
Jan 24, 2014·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Sung Ae KohHun Mo Ryoo
Mar 21, 2009·Medical Care·Mette L RurupBregje D Onwuteaka-Philipsen
Nov 15, 2011·Current Medical Research and Opinion·Sebastiano Mercadante
Jan 10, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Karen C ChungMartin Zagari
Oct 30, 2012·Journal of Pain and Symptom Management·Sebastiano MercadanteUNKNOWN Home Care—Italy Group
Aug 12, 2008·Journal of Pain and Symptom Management·Mette L RurupBregje D Onwuteaka-Philipsen
Dec 13, 2006·Journal of Pain and Symptom Management·Russell K PortenoyPerry G Fine
Dec 17, 2009·Internal Medicine Journal·B R Ensor, T P Middlemiss
Mar 23, 2006·Intensive & Critical Care Nursing : the Official Journal of the British Association of Critical Care Nurses·Erwin J O Kompanje
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Apr 10, 2015·International Journal of Clinical Pharmacy·Anniek D MasmanRon A A Mathôt
Apr 16, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Stephen J StapletonDiana J Wilkie
Sep 11, 2010·The Korean Journal of Internal Medicine·Jung Han KimJoo Young Jung
Jan 8, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Seigo MinamiKiyoshi Komuta
Aug 6, 2016·Journal of Palliative Medicine·Anniek D MasmanTeun van Gelder
Sep 15, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B AabomH Stovring
Sep 10, 2010·The American Journal of Hospice & Palliative Care·Sebastiano MercadanteAlessandra Casuccio
May 5, 2010·The American Journal of Hospice & Palliative Care·Sebastiano MercadanteAlessandra Casuccio
Jun 13, 2018·Journal of Palliative Medicine·Takaaki HasegawaTatsuo Akechi
Jan 6, 2019·Healthcare·Marc-Antoine MarquisFrance Gauvin
Nov 23, 2016·BMC Palliative Care·Anon SathornviriyapongThunyarat Anothaisintawee
Oct 17, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dana L AbrahamJennifer A Pruskowski

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