Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development

Pediatrics
A N HaggstromI J Frieden

Abstract

Large facial infantile hemangiomas have higher rates of complications than small localized hemangiomas, more often require treatment, and can be associated with neurological, ophthalmologic, and cardiac anomalies (PHACE syndrome). The anatomic patterns of these hemangiomas are often referred to as "segmental" despite a lack of precise anatomic definitions. Our study aims to define "segmental" hemangiomas based on clinically observed patterns. Our secondary goal is to relate the observed patterns to currently accepted developmental patterns to gain insight into hemangioma pathogenesis and craniofacial development. Photographic data were extracted from a large cohort of patients with infantile hemangiomas. We mapped 294 hemangiomas and recorded common morphologic patterns. Anatomic descriptions of the most common patterns were described and compared with accepted concepts of craniofacial development. Four primary segments were identified (Seg1-Seg4). Seg2 and Seg3 correspond with the previously recognized maxillary and mandibular prominences. Seg1 and Seg4 differ from standard human embryology texts. The frontotemporal segment, Seg1, encompasses the lateral forehead, anterior temporal scalp, and lateral frontal scalp. The segment...Continue Reading

References

Jan 1, 1990·Annals of the New York Academy of Sciences·D M Noden
Sep 18, 1998·Mechanisms of Development·P Francis-WestA Graveson
Mar 22, 2001·Journal of the American Academy of Dermatology·R Happle, A Assim
May 8, 2001·Cells, Tissues, Organs·G Allt, J G Lawrenson
Jul 11, 2001·The Journal of Pediatrics·D W MetryI J Frieden
Jan 5, 2002·The Journal of Comparative Neurology·Johannes KornHaymo Kurz
Jan 11, 2002·Developmental Biology·Xiaobing JiangGillian M Morriss-Kay
Jul 23, 2003·Archives of Dermatology·Milton WanerMartin C Mihm

❮ Previous
Next ❯

Citations

Apr 23, 2008·Pediatric Cardiology·Rohit P RaoPeter C Frommelt
Jun 29, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Katherine B Puttgen, Doris D M Lin
Aug 11, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Katherine B PuttgenSally E Mitchell
Jan 23, 2013·American Journal of Clinical Dermatology·Eun-Kyung Mary KwonBeth A Drolet
Mar 29, 2008·Lymphatic Research and Biology·Carmen M BarnésJudah Folkman
Nov 14, 2006·Current Opinion in Otolaryngology & Head and Neck Surgery·Carol J Macarthur
Aug 20, 2009·Pediatric Dermatology·Denise W MetryIlona J Frieden
Aug 20, 2009·Pediatric Dermatology·Elizabeth Alvarez ConnellyMilton Waner
Jun 22, 2010·Pediatric Dermatology·Ki-Young SuhIlona J Frieden
Mar 10, 2011·Pediatric Dermatology·Lorea BagazgoitiaEulalia Baselga
Sep 29, 2011·Pediatric Dermatology·Meghan W ThomasAnnette M Wagner
Oct 24, 2013·AJR. American Journal of Roentgenology·Ramya KolliparaLisa H Lowe
May 1, 2012·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Moise L Levy
Sep 5, 2009·Clinical Medicine : Journal of the Royal College of Physicians of London·Nerys Roberts
Dec 20, 2013·Plastic and Reconstructive Surgery·Pawel SzychtaWill Anderson
Jun 6, 2014·Dermatology Research and Practice·Basheir A Hassan, Khalid S Shreef
Jul 16, 2014·Clinics in Dermatology·Bernardo Gontijo
Jun 17, 2014·Progress in Retinal and Eye Research·Giovanni CasiniPaola Bagnoli
Jul 16, 2014·Clinics in Dermatology·Francine Blei, Ascanio Guarini
Jan 19, 2008·AJNR. American Journal of Neuroradiology·Mauricio Castillo
Jan 29, 2008·AJNR. American Journal of Neuroradiology·V S OzaF Blei
Aug 14, 2010·AJNR. American Journal of Neuroradiology·C P HessA J Barkovich
Oct 19, 2010·Indian Journal of Pediatrics·Siddram J PatilRavindra R Battu
Dec 5, 2008·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Behfar EivaziJochen A Werner
Mar 21, 2016·Clinical Imaging·Mark D MamloukErin F Mathes
Mar 19, 2014·Pediatric Clinics of North America·Katherine B Püttgen
May 1, 2013·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·I DreyfusJ Mazereeuw-Hautier
Apr 27, 2013·International Journal of Oral and Maxillofacial Surgery·R R SadykovH R Metellmann
Apr 6, 2013·Dermatologic Clinics·Kristen E Holland, Beth A Drolet
Oct 17, 2014·The British Journal of Dermatology·A N Haggstrom, I J Frieden
Jul 1, 2014·The British Journal of Dermatology·R WaelchliV A Kinsler
Oct 16, 2015·Acta Paediatrica·Pieta R WinterSwee T Tan
May 9, 2012·Experimental and Molecular Pathology·Alexandra KleimanZia A Khan
May 17, 2012·Otolaryngologic Clinics of North America·Larry D Hartzell, Lisa M Buckmiller
Mar 1, 2012·Seminars in Roentgenology·Lisa H LoweAmanda J Scherbel
Aug 16, 2011·Annales de pathologie·Sylvie Fraitag
Dec 21, 2010·The Journal of Pediatrics·Laura SillardJean-Philippe Lacour
Nov 26, 2010·Clinics in Plastic Surgery·Sheilagh M Maguiness, Marilyn G Liang
Aug 28, 2010·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·W J M HolmesS H Liew
Aug 24, 2010·Journal of the American Academy of Dermatology·Anna M JuernIlona J Frieden
Oct 5, 2010·Pediatric Clinics of North America·Kristen E Holland, Beth A Drolet
Jun 29, 2010·Seminars in Cutaneous Medicine and Surgery·Sheilagh M Maguiness, Ilona J Frieden
Mar 30, 2010·Neuro-Chirurgie·P DhellemmesM Vinchon
Mar 9, 2010·La Presse médicale·Christine Léauté-Labrèze, Véronique Sans-Martin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.