Patterns of invasion and histological growth as prognostic indicators in urothelial carcinoma of the upper urinary tract

Virchows Archiv : an International Journal of Pathology
Cord LangnerRichard E Zigeuner

Abstract

The biological significance of squamous and glandular differentiation and different patterns of invasion in upper urinary tract urothelial carcinoma is unclear. We reviewed 268 cases of consecutive upper urinary tract carcinomas with respect to the presence of squamous and/or glandular differentiation and different patterns of invasion (nodular, trabecular, and infiltrative) and correlated data with patient outcome. Squamous or glandular differentiation occurred in 47/268 (18%) tumors and its presence correlated with high tumor stage (P<0.001) and grade (P<0.001). Invasive patterns were nodular in 49/227 (22%), trabecular in 95/227 (42%), and infiltrative in 83/227 (37%) tumors. The nodular pattern prevailed in low stage (P<0.001) and low-grade (P<0.001) tumors, whereas the infiltrative pattern prevailed in high stage (P<0.001) and high-grade (P<0.001) tumors. Multivariate analysis proved that tumor stage (P<0.001) and the infiltrative pattern (P<0.001) are independent predictors of metastasis-free survival, whereas tumor grade and squamous and glandular differentiation lacked independent influence on patient outcome. In conclusion, the infiltrative pattern of invasion significantly correlated with advanced disease and poor pat...Continue Reading

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Citations

Jun 18, 2011·World Journal of Urology·Grégory VerhoestKarim Bensalah
Jun 6, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Liang ChengAntonio Lopez-Beltran
Apr 22, 2009·Scandinavian Journal of Urology and Nephrology·Stefan DenzingerWolfgang Otto
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Dec 25, 2008·Pathology, Research and Practice·Ljubinka Jankovic VelickovicVladisav Stefanovic
Jan 22, 2008·European Urology·Richard Zigeuner, Karl Pummer
Jan 22, 2009·Cancer·Vitaly MargulisUNKNOWN Upper Tract Urothelial Carcinoma CollaborationThe Upper Tract Urothelial Carcinoma Collaboration
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Mar 5, 2015·Cancer Treatment Reviews·Jeffrey J LeowJoaquim Bellmunt
Nov 18, 2006·Virchows Archiv : an International Journal of Pathology·Alexandra WinklerCord Langner
Feb 24, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Wolfgang OttoArndt Hartmann
Jul 6, 2011·Nature Reviews. Urology·Thomas F ChromeckiShahrokh F Shariat
May 29, 2012·Virchows Archiv : an International Journal of Pathology·Magdalena M GilgCord Langner
Jul 19, 2011·Journal of Computer Assisted Tomography·Manjiri K DigheJonathan Wright
Jan 18, 2020·Virchows Archiv : an International Journal of Pathology·Inês RolimAntonio Lopez-Beltran
Jul 29, 2017·Journal of the Chinese Medical Association : JCMA·Cheng-Huang ShenGuang-Dar Juang
Jul 5, 2021·Virchows Archiv : an International Journal of Pathology·Koorosh HaghayeghiAli Amin

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