Patterns of joint involvement in juvenile idiopathic arthritis and prediction of disease course: A prospective study with multilayer non-negative matrix factorization

PLoS Medicine
Simon W M EngReACCh-Out Research Consortium

Abstract

Joint inflammation is the common feature underlying juvenile idiopathic arthritis (JIA). Clinicians recognize patterns of joint involvement currently not part of the International League of Associations for Rheumatology (ILAR) classification. Using unsupervised machine learning, we sought to uncover data-driven joint patterns that predict clinical phenotype and disease trajectories. We analyzed prospectively collected clinical data, including joint involvement using a standard 71-joint homunculus, for 640 discovery patients with newly diagnosed JIA enrolled in a Canada-wide study who were followed serially for five years, treatment-naïve except for nonsteroidal anti-inflammatory drugs (NSAIDs) and diagnosed within one year of symptom onset. Twenty-one patients had systemic arthritis, 300 oligoarthritis, 125 rheumatoid factor (RF)-negative polyarthritis, 16 RF-positive polyarthritis, 37 psoriatic arthritis, 78 enthesitis-related arthritis (ERA), and 63 undifferentiated arthritis. At diagnosis, we observed global hierarchical groups of co-involved joints. To characterize these patterns, we developed sparse multilayer non-negative matrix factorization (NMF). Model selection by internal bi-cross-validation identified seven joint pa...Continue Reading

References

Oct 9, 2007·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Brooke E GilliamTerry L Moore

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Citations

Jul 31, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yongwan LimKrishna S Nayak
May 16, 2019·Current Opinion in Rheumatology·Jaime GuzmanThomas Loughin
Jun 7, 2019·Current Opinion in Rheumatology·Peter A NigrovicSusan D Thompson
Jan 8, 2020·Nature Reviews. Rheumatology·Aridaman Pandit, Timothy R D J Radstake
Jul 19, 2020·Clinical Reviews in Allergy & Immunology·Mengdi JiangPeter E Lipsky
Oct 25, 2020·Rheumatology·Patrick D W Kiely, Mark E Lloyd
Jan 22, 2021·Expert Review of Clinical Immunology·Simon W M EngQuaid Morris
Mar 19, 2021·Nature Reviews. Rheumatology·Peter A NigrovicAlberto Martini
Jul 11, 2021·Advances in Pediatrics·Deborah McCurdy, Miriam F Parsa

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Methods Mentioned

BETA
PCA

Software Mentioned

TRIPOD
BiCV
JIA
Python
R
Circos

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