PMID: 6974041Mar 1, 1981Paper

Patterns of late replication in X chromosomes of human lymphoid cells

Cancer Genetics and Cytogenetics
S A LattH Lazarus

Abstract

Two predominant patterns of late X replication were observed in both short-term and established human lymphoid cultures. One pattern was found in a minority of short-term cultured T-cell metaphases, in most lectin-stimulated B cells, and, with minor variations, in established B-cell lines. In these cells, DNA replication terminated in the distal part of the long arm of the late X. A different pattern was found in the majority of lectin-simulated T cells and in the T-cell line CCRF-CEM. These cells exhibited terminal replication in a region of the long arm of the late X that was nearer to the centromere. It is speculated that the variations in replication patterns correlate with phenotypic and functional characteristics of human lymphoid subsets.

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Citations

May 1, 1988·Human Genetics·K S ReddyD G Papworth
May 1, 1983·Cancer Genetics and Cytogenetics·V Lindgren, R A Farber
Feb 1, 1985·Cancer Genetics and Cytogenetics·M Debiec-RychterD Zajazkowska
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M Schmidt, B R Migeon
Aug 1, 1992·American Journal of Medical Genetics·T Webb
Jun 1, 1987·Jinrui idengaku zasshi. The Japanese journal of human genetics·Y YamamotoT Koizumi

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