Patterns of leukocyte counts on admissions for acute heart failure--presentation and outcome--results from a community based registry

International Journal of Cardiology
Olga Milo-CotterGad Cotter

Abstract

To determine the correlation between differential white blood cell (WBC) count and characteristics and outcome of acute heart failure (AHF) syndromes. Previous studies suggested that different white blood cell count patterns are related to outcome in patients with heart failure (HF) and other cardiovascular disorders. Data from all qualifying AHF admissions to a city hospital (n=340) was prospectively collected. Patients were followed from admission up to 6 months post-discharge. The relationship between patients' demographics, clinical and laboratory characteristics and outcome were assessed in relation to WBC count and lymphocyte to WBC ratio (LWR). WBC count >10,100×10 (9)/L (upper tertile) on admission was associated with higher admission blood pressure, lower oxygen saturation, higher heart rate and increased troponin, with no impact on either short-term worsening HF or long-term adverse outcome. Lower LWR was associated with higher BUN and troponin and lower hemoglobin, but not with a distinct clinical presentation. The lower LWR tertile (≤13%) was associated with a 60% increase in worsening HF risk and a substantially higher 1 month (15% versus 2%) and 6 months mortality (23% vs. 3%) for lowest versus highest quartile (p...Continue Reading

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Citations

Oct 12, 2012·Heart Failure Reviews·Muthiah VaduganathanMihai Gheorghiade
Aug 25, 2012·The American Journal of Cardiology·Stephen J GreeneUNKNOWN EVEREST Trial Investigators
Jan 10, 2012·International Journal of Cardiology·Eduard ShantsilaGregory Y H Lip
Jan 25, 2011·The American Journal of Cardiology·Shanmugam UthamalingamRobert Capodilupo
Dec 21, 2016·Pacing and Clinical Electrophysiology : PACE·Naoaki HashimotoIsao Kubota
Aug 20, 2016·Journal of Cardiovascular Medicine·Valentina CarubelliMarco Metra

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