PMID: 3213952Jan 1, 1988Paper

Patterns of maturation of somatotopical distribution of corticospinal neurons in postnatal rats. A WGA-HRP study

Anatomy and Embryology
T UozumiT Kanaseki

Abstract

To better comprehend somatotopic development of the corticospinal projection system, wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) was injected into cervical or lumbar enlargement of the spinal cord of postnatal rats. The cervical projecting neurons appeared first in the middle of the lateral surface of the posterior frontal and anterior parietal cortex on the second postnatal day (postnatal day one, P1). By P3, labeled neurons were distributed in the rostral two-thirds of the cortex, with concentrations both on the same cortex as in P1 and on the dorsomedial part of the frontal cortex. Size of the labeled area was gradually reduced between P3 and P12 to attain an adult organization: three discrete clusters of labeled neurons were isolated in the dorsomedial part of the frontal cortex, the middle of the lateral surface of the posterior frontal and anterior parietal cortex, and in the temporal cortex. The lumbar projecting neurons first appeared in the dorsomedial part of the parietal cortex, on P4. Size of the lumbar projecting area increased by P6 and decreased by P12 to attain the pattern seen in adult animals. Our findings suggest that 1) potential "pioneer fibers" reaching the cervical enlargement ori...Continue Reading

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Citations

Apr 15, 1994·Brain Research. Developmental Brain Research·M H CurfsP J Dederen
Mar 19, 2005·The Journal of Physiology·Kerry D WaltonRodolfo Llinás
Nov 4, 2005·Journal of Neurophysiology·Tsutomu KamiyamaMasaki Sakurai
Jan 23, 1999·Journal of Neurophysiology·K M JacobsD A Prince

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