PMID: 8939820Dec 1, 1996Paper

Patterns of meiotic double-strand breakage on native and artificial yeast chromosomes

Chromosoma
S KleinG Simchen

Abstract

The preferred positions for meiotic double-strand breakage were mapped on Saccharomyces cerevisiae chromosomes I and VI, and on a number of yeast artificial chromosomes carrying human DNA inserts. Each chromosome had strong and weak double-strand break (DSB) sites. On average one DSB-prone region was detected by pulsed-field gel electrophoresis per 25 kb of DNA, but each chromosome had a unique distribution of DSB sites. There were no preferred meiotic DSB sites near the telomeres. DSB-prone regions were associated with all of the known "hot spots" for meiotic recombination on chromosomes I, III and VI.

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Citations

Jan 14, 2005·Molecular Biology of the Cell·Yair KliegerGiora Simchen
Jan 11, 2013·Nucleic Acids Research·Wei ChenKuo-Chen Chou
Jun 20, 2008·Genetics·Arnold B BartonDavid B Kaback
Jan 29, 2014·International Journal of Molecular Sciences·Wang-Ren QiuKuo-Chen Chou
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Sep 1, 2005·Cancer Letters·Akihisa Takahashi, Takeo Ohnishi
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Oct 24, 2003·Genetics·Arnold B BartonDavid B Kaback
Oct 23, 1997·Genes & Development·G S Roeder

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