Patterns of microstructural white matter abnormalities and their impact on cognitive dysfunction in the various phases of type I bipolar disorder

Journal of Affective Disorders
Paola MagioncaldaMario Amore

Abstract

In recent years, diffusion tensor imaging (DTI) studies have detected subtle microstructural abnormalities of white matter (WM) in type I bipolar disorder (BD). However, WM alterations in the different phases of BD remain to be explored. The aims of this study is to investigate the WM alterations in the various phases of illness and their correlations with clinical and neurocognitive features. We investigated the DTI-derived fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) in patients with type I BD (n=61) subdivided in manic (n=21), depressive (n=20) and euthymic phases (n=20) vs. healthy controls (n=42), using a tract-based spatial statistics (TBSS) approach. Then, we investigated whether the subgroups of patients in the various phases of illness present different patterns of WM abnormalities. Finally we studied the correlations between WM alterations and clinical-cognitive parameters. We found a widespread alteration in WM microstructure (decrease in FA and increase in MD and RD) in BD when compared to controls. The various subgroups of BD showed different spatial patterns of WM alterations. A gradient of increasing WM abnormalities from the euthymic (low degree and locali...Continue Reading

References

Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Feb 1, 1984·The British Journal of Psychiatry : the Journal of Mental Science·E J Bidzińska
Apr 1, 1996·Journal of Clinical Psychopharmacology·H S Akiskal
Jul 1, 1997·Journal of Psychiatric Research·J C Soares, J J Mann
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
Nov 27, 2002·Journal of Affective Disorders·Seema Quraishi, Sophia Frangou
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Jun 23, 2004·Journal of Clinical Psychopharmacology·John M Davis, Nancy Chen
Feb 5, 2008·The American Journal of Psychiatry·Mary L PhillipsDavid J Kupfer
Jun 10, 2008·Brain Research Reviews·Konstantinos N FountoulakisConstantin Bouras
Sep 16, 2008·European Psychiatry : the Journal of the Association of European Psychiatrists·Athanasios Koukopoulos, S Nassir Ghaemi
Dec 9, 2008·NeuroImage·Mark W WoolrichStephen M Smith
Mar 4, 2009·European Archives of Psychiatry and Clinical Neuroscience·Marcus V ZanettiMary L Phillips
Jul 25, 2009·Bipolar Disorders·Michèle WessaMarie-Laure Paillère-Martinot
Oct 13, 2009·Nature Neuroscience·Jan ScholzHeidi Johansen-Berg
Dec 18, 2009·Biological Psychiatry·Yekta DowlatiKrista L Lanctôt
Jan 29, 2010·Journal of Neural Transmission·Serene HengKang Sim
Jun 18, 2010·Psychiatry Research·Dost OngürPerry F Renshaw
Sep 3, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Warren D TaylorP Murali Doraiswamy
Oct 12, 2010·Biological Psychiatry·Francesco BenedettiPaolo Brambilla
Nov 26, 2010·Journal of Affective Disorders·Judith ProudfootGordon Parker
Feb 3, 2011·Journal of Psychiatry & Neuroscience : JPN·Sven HallerPanteleimon Giannakopoulos
Jun 1, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·François-Eric VederineJosselin Houenou
Aug 17, 2011·Bipolar Disorders·Francesco BenedettiMassimo Filippi
Sep 13, 2011·Trends in Cognitive Sciences·Vinod Menon
Oct 22, 2011·Neurobiology of Aging·Julia MiralbellMaria Mataró
Sep 8, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francesco BenedettiEnrico Smeraldi
Sep 20, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francesco BenedettiEnrico Smeraldi

❮ Previous
Next ❯

Citations

Jun 19, 2016·Journal of Affective Disorders·Bartholomeus C M 'Benno' HaarmanLeonardo Cerliani
Dec 7, 2019·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Genevieve McPhilemyDara M Cannon
Apr 17, 2021·Molecular Psychiatry·Paola Magioncalda, Matteo Martino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.