Patterns of molecular evolution in Caenorhabditis preclude ancient origins of selfing.

Genetics
Asher D CutterNicole L Washington

Abstract

The evolution of self-fertilization can mediate pronounced changes in genomes as a by-product of a drastic reduction in effective population size and the concomitant accumulation of slightly deleterious mutations by genetic drift. In the nematode genus Caenorhabditis, a highly selfing lifestyle has evolved twice independently, thus permitting an opportunity to test for the effects of mode of reproduction on patterns of molecular evolution on a genomic scale. Here we contrast rates of nucleotide substitution and codon usage bias among thousands of orthologous groups of genes in six species of Caenorhabditis, including the classic model organism Caenorhabditis elegans. Despite evidence that weak selection on synonymous codon usage is pervasive in the history of all species in this genus, we find little difference among species in the patterns of codon usage bias and in replacement-site substitution. Applying a model of relaxed selection on codon usage to the C. elegans and C. briggsae lineages suggests that self-fertilization is unlikely to have evolved more than approximately 4 million years ago, which is less than a quarter of the time since they shared a common ancestor with outcrossing species. We conclude that the profound c...Continue Reading

References

Feb 1, 1974·Genetical Research·J M Smith, J Haigh
Feb 17, 1968·Nature·M Kimura
Aug 1, 1993·Genetics·B CharlesworthD Charlesworth
Nov 21, 1997·Computer Applications in the Biosciences : CABIOS·Z Yang
Dec 16, 1998·Science·UNKNOWN C. elegans Sequencing Consortium
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·L Duret, D Mouchiroud
Aug 7, 2001·Genetical Research·M T Morgan
Sep 15, 2001·Science·S K KimG S Davidson
Oct 5, 2001·Trends in Genetics : TIG·A MiraN A Moran
Oct 30, 2001·Current Opinion in Genetics & Development·D Charlesworth, S I Wright
Jun 5, 2002·Genome Research·Avril Coghlan, Kenneth H Wolfe
Aug 30, 2002·Molecular Biology and Evolution·Stephen I WrightDeborah Charlesworth
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Andrea J Betancourt, Daven C Presgraves
Apr 16, 2003·Molecular Ecology·Stephen I WrightDeborah Charlesworth
Apr 30, 2003·Molecular Biology and Evolution·Dmitri A PetrovAaron E Hirsh
Jul 2, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Deborah Charlesworth
Jul 3, 2003·Evolution; International Journal of Organic Evolution·John R Pannell
Jul 23, 2003·Genetical Research·Asher D CutterSamuel Ward
Aug 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gwenaël Piganeau, Adam Eyre-Walker
Sep 4, 2003·Genome Research·Li LiDavid S Roos
Apr 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·N SUEOKA
Nov 19, 2003·PLoS Biology·Lincoln D SteinRobert H Waterston
Nov 25, 2003·Nature·Titia Sijen, Ronald H A Plasterk
Nov 25, 2003·Science·Michael Lynch, John S Conery
Nov 26, 2003·Journal of Evolutionary Biology·A D Cutter, B A Payseur
Dec 19, 2003·Nucleic Acids Research·John ParkinsonMark Blaxter
Feb 28, 2004·Bioinformatics·John ParkinsonMark Blaxter
Apr 3, 2004·Bioinformatics·Fran Supek, Kristian Vlahovicek
May 4, 2004·Evolution; International Journal of Organic Evolution·Asher D Cutter
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Karin KiontkeDavid H A Fitch

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Citations

Jan 15, 2013·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Touqeer AhmadWen-Wu Guo
Mar 16, 2011·Genome Biology and Evolution·C A WhittleH Johannesson
Mar 10, 2010·The Journal of Heredity·Jennifer L AndersonPatrick C Phillips
Mar 18, 2009·Molecular Biology and Evolution·Asher D CutterRosalind L Murray
Apr 19, 2013·Proceedings. Biological Sciences·Stephen I WrightTanja Slotte
Nov 23, 2011·BMC Evolutionary Biology·Karin C KiontkeDavid H A Fitch
Apr 16, 2011·BMC Evolutionary Biology·Rosalind L MurrayAsher D Cutter
May 2, 2008·BMC Evolutionary Biology·Laurence Loewe, Asher D Cutter
Nov 6, 2008·BMC Evolutionary Biology·Pär K Ingvarsson
Apr 13, 2010·Genetics·Asher D Cutter, Aneil F Agrawal
Oct 5, 2011·Genetics·Natalia S MorsciMaureen M Barr
Jun 25, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Spencer C H BarrettStephen I Wright
Apr 7, 2012·Trends in Genetics : TIG·Cristel G ThomasEric S Haag
Oct 4, 2015·Journal of Evolutionary Biology·M Hartfield
Mar 3, 2011·Fungal Genetics and Biology : FG & B·C A WhittleH Johannesson
Jan 10, 2009·Current Opinion in Genetics & Development·Jonathan M Flowers, Michael D Purugganan
Nov 19, 2014·Evolution; International Journal of Organic Evolution·Amanda Kyle Gibson, Jesualdo Arturo Fuentes
Jul 24, 2010·Evolution; International Journal of Organic Evolution·Charles F BaerAmbuj Upadhyay
Feb 21, 2013·The New Phytologist·Boris Igic, Jeremiah W Busch
Oct 21, 2010·Molecular Ecology·Guo-Xiu WangAsher D Cutter
May 27, 2010·Evolution; International Journal of Organic Evolution·Juan S EscobarSylvain Glémin
Jan 8, 2013·Evolution; International Journal of Organic Evolution·Sylvain Glémin, Joëlle Ronfort
Dec 5, 2013·Evolution; International Journal of Organic Evolution·Anastasia GiotiHanna Johannesson
Mar 29, 2014·Journal of Evolutionary Biology·S Glémin, A Muyle
Jul 1, 2014·Journal of Evolutionary Biology·T SchwanderD Roze
Jul 2, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Asher D Cutter
Jul 15, 2015·Journal of Biomolecular Structure & Dynamics·Pratim ChakrabortiSubhasish Mukhopadhyay
Aug 19, 2015·Genome Génome / Conseil National De Recherches Canada·Kun ZhouGuoxiu Wang
May 17, 2015·Molecular Biology and Evolution·Concetta BurgarellaSylvain Glémin
May 23, 2015·BMC Evolutionary Biology·Michael F PalopoliPatrick C Phillips
May 23, 2014·Molecular Phylogenetics and Evolution·Pádraic CorcoranHanna Johannesson
Nov 28, 2008·Current Biology : CB·Asher D Cutter
Mar 20, 2015·ELife·Jody M HansenGillian M Stanfield

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