Patterns of neural activity associated with differential acute locomotor stimulation to cocaine and methamphetamine in adolescent versus adult male C57BL/6J mice.

Neuroscience
Jonathan A ZombeckJ S Rhodes

Abstract

Adolescence is a time period when major changes occur in the brain with long-term consequences for behavior. One ramification is altered responses to drugs of abuse, but the specific brain mechanisms and implications for mental health are poorly understood. Here, we used a mouse model in which adolescents display dramatically reduced sensitivity to the acute locomotor stimulating effects of cocaine and methamphetamine. The goal was to identify key brain regions or circuits involved in the differential behavior. Male adolescent (postnatal day (PN), 30-35) and young adult (PN, 69-74) C57BL/6J mice were administered an i.p. injection of cocaine (0, 15, 30 mg/kg) or methamphetamine (0, 2, 4 mg/kg) and euthanized 90 min later. Locomotor activity was monitored continuously in the home cage by video tracking. Immunohistochemical detection of Fos protein was used to quantify neuronal activation in 16 different brain regions. As expected, adolescents were less sensitive to the locomotor stimulating effects of cocaine and methamphetamine as indicated by a rightward shift in the dose response relationship. After a saline injection, adolescents showed similar levels of Fos as adults in all regions except the dorsal caudate (CPuD) and later...Continue Reading

References

Apr 29, 1977·Psychopharmacology·L ShusterA Bates
Jul 1, 1990·Trends in Neurosciences·A M Graybiel
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A M GraybielH A Robertson
Jan 2, 1995·The Journal of Comparative Neurology·B E KosofskyS E Hyman
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·B K Tolliver, J M Carney
May 1, 1994·Pharmacology, Biochemistry, and Behavior·B K Tolliver, J M Carney
Nov 21, 1995·Brain Research. Developmental Brain Research·M H TeicherJ C Hostetter
Mar 25, 1998·Pharmacology, Biochemistry, and Behavior·M R AzarB C Jones
Aug 13, 1998·Pharmacology, Biochemistry, and Behavior·K J SnyderL P Spear
Sep 28, 1998·Brain Research. Developmental Brain Research·F I TaraziR J Baldessarini
Nov 7, 1998·Brain Research. Developmental Brain Research·C A BolanosD Jackson
Sep 24, 1999·Nature Neuroscience·J N GieddJ L Rapoport
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·E J NestlerD W Self
May 22, 2003·Pharmacology, Biochemistry, and Behavior·Stefan D SchlussmanMary Jeanne Kreek
Sep 16, 2003·Drugs of Today·Christian P MüllerJoseph P Huston
Dec 17, 2003·Behavioral Neuroscience·Justin S RhodesStephen C Gammie
Jul 15, 2004·Annals of the New York Academy of Sciences·Jay N Giedd
Sep 29, 2004·Neurotoxicology and Teratology·Lois E McCarthyMichelle E Ehrlich
Feb 15, 2005·Physiology & Behavior·Antoniette M Maldonado, Cheryl L Kirstein
Jul 7, 2005·Behavioral Neuroscience·Justin S RhodesJohn C Crabbe
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Venetia ZachariouEric J Nestler
Sep 17, 2005·Journal of Psychopharmacology·Briony J Catlow, Cheryl L Kirstein
Sep 24, 2005·Physiology & Behavior·Antoniette M Maldonado, Cheryl L Kirstein
Jun 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kyle J FrantzLoren H Parsons
Jul 21, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George V Rebec
Jan 26, 2007·The American Journal of Nursing·Fran Mennick
Feb 15, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Junran CaoFrances M Leslie
Dec 25, 2007·Physiology & Behavior·Jonathan A ZombeckJustin S Rhodes
Feb 1, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michelle NiculescuEllen M Unterwald
Feb 16, 2008·Pharmacology, Biochemistry, and Behavior·Sarah L ParylakCynthia M Kuhn
Jul 4, 2008·Neuroreport·Michael R Tilley, Howard H Gu

❮ Previous
Next ❯

Citations

Jul 4, 2012·Psychopharmacology·Natalie E ZlebnikMarilyn E Carroll
May 28, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I Z MathewsC M McCormick
Nov 16, 2010·The European Journal of Neuroscience·Chiara ProcacciniEsa R Korpi
Mar 15, 2011·Physiology & Behavior·Melissa-Ann L ScottiStephen C Gammie
Sep 13, 2013·The Journal of Toxicological Sciences·Masafumi TomitaOsamu Miyamoto
Jun 7, 2017·British Journal of Pharmacology·Linda D SimmlerRandy D Blakely

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.