Patterns of neuroaxis dissemination of gliomas: suggestion of a classification based on magnetic resonance imaging findings

Surgical Neurology
Kelly Cristina BordignonLuiz Gustavo Morato Pinto de Almeida

Abstract

Local invasion is the hallmark of malignant glioma dissemination. Leptomeningeal dissemination, a serious complication of malignant gliomas, has been increasingly observed. To correlate the physiopathologic mechanisms and the magnetic resonance imaging patterns of neuroaxis dissemination, a classification of malignant glioma dissemination is proposed (Instituto de Neurologia de Curitiba Classification). This classification includes the following patterns of dissemination: leptomeningeal (type I), nodular (type Ia), diffuse (type Ib); subependymal (type II); satellite (type IIIa, IIIb); and mixed (type IV), combination of 2 or more previous types. Of 138 patients with histologically confirmed gliomas treated between 2000 and 2004, 10 presented neuroaxis dissemination and were evaluated. The distribution of dissemination patterns was as follows: subependymal, 4 of 10; diffuse leptomeningeal, 1 of 10; nodular leptomeningeal, 1 of 10; and satellite, 4 of 10. Mean interval between primary tumor and dissemination was 4 months. The most frequent glioma dissemination risk factor was entering the ventricular system during surgery. Improvements in our diagnostic imaging capabilities have contributed to a better understanding of the patte...Continue Reading

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Citations

Jun 26, 2008·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Gloria RoldánElizabeth Yan
Jul 31, 2013·Journal of Neurosurgery. Pediatrics·Tomohiro KawaguchiTeiji Tominaga
Oct 12, 2016·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Yoshihito KadotaYasuyuki Yamashita
Jun 7, 2011·Journal of Neuro-oncology·Andrew J TsungNicole A Shonka
Dec 31, 2020·Cancers·Cristina BirzuGiuseppe Lombardi
Jan 5, 2021·The Oncologist·Cristina BirzuAhmed Idbaih
May 21, 2021·Frontiers in Veterinary Science·R Timothy BentleyJohn H Rossmeisl

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