Patterns of nodal metastases in palpable medullary thyroid carcinoma: recommendations for extent of node dissection

Annals of Surgery
Jeffrey F Moley, M K DeBenedetti

Abstract

To establish the frequency, pattern and location of cervical lymph node metastases from palpable medullary thyroid carcinoma (MTC). Recommendations are made regarding the extent of surgery for this tumor. Medullary thyroid carcinoma is a tumor of neuroendocrine origin that does not concentrate iodine. Surgical extirpation of the thyroid tumor and cervical node metastases is the only potentially curative therapeutic option. Patterns of node metastases in the neck and guidelines for the extent of dissection for palpable MTC are not well established. Seventy-three patients underwent thyroidectomy for palpable MTC with immediate or delayed central and bilateral functional neck dissections. The number and location of lymph node metastases in the central (levels VI and VII) and bilateral (levels II to V) nodal groups were noted and were correlated with the size and location of the primary thyroid tumor. Intraoperative assessment of nodal status by palpation and inspection by the surgeon was correlated with results of histologic examination. Patients with unilateral intrathyroid tumors had lymph node metastases in 81% of central node dissections, 81% of ipsilateral functional (levels II to V) dissections, and 44% of contralateral func...Continue Reading

Associated Clinical Trials

Apr 24, 2013·James Gulley, M.D., James Gulley, M.D.

References

Mar 1, 1975·Cancer·G C ChongL H Woolner
Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·H ScherüblR Ziegler
Mar 1, 1966·Journal of Clinical Pathology·E D WilliamsI Doniach
Feb 1, 1983·International Journal of Radiation Oncology, Biology, Physics·P RougierM Tubiana
Jul 1, 1983·The Journal of Clinical Endocrinology and Metabolism·M F SaadN A Samaan
Apr 1, 1980·American Journal of Surgery·R L RossiJ Werber
Jun 1, 1997·Annals of Surgery·J F MoleyM K DeBenedetti
Jan 1, 1959·The Journal of Clinical Endocrinology and Metabolism·J B HAZARDG CRILE

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Next ❯

Citations

Jun 1, 2000·Cancer Control : Journal of the Moffitt Cancer Center·G W Randolph, D Maniar
Feb 27, 2007·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·O Gimm, H Dralle
Aug 8, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Brendon G ConryJamshed B Bomanji
Mar 5, 2013·Langenbeck's Archives of Surgery·Henning DralleUNKNOWN German Societies of General and Visceral Surgery; Endocrinology; Nuclear Medicine; Pathology; Radiooncology; Oncological Hem
May 21, 2013·Langenbeck's Archives of Surgery·Jakob DahlbergSvante Jansson
Jun 3, 2008·Surgery Today·Marcos R TavaresAlberto Ferraz
Jun 12, 2002·Current Treatment Options in Oncology·E Kebebew, O H Clark
Aug 29, 2003·Current Treatment Options in Oncology·Jeffrey F Moley
Jun 22, 2005·Current Treatment Options in Oncology·Amber Traugott, Jeffrey F Moley
Jun 22, 2005·Current Treatment Options in Oncology·Frank Jay Quayle, Jeffrey F Moley
Apr 1, 2010·Indian Journal of Surgical Oncology·Devendra A ChaukarMitali R Dandekar
May 24, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A Machens, H Dralle
Jun 1, 2005·Journal of the American College of Surgeons·Electron KebebewJocelyn Grunwell
Oct 5, 2011·The Journal of Biological Chemistry·Sujeenthar TharmalingamDavid R Hampson
Jun 10, 2004·Cancer Biotherapy & Radiopharmaceuticals·Maria ParisellaAlberto Signore
Jul 7, 2007·Thyroid : Official Journal of the American Thyroid Association·Simona Grozinsky-GlasbergMordechai Lapidot
May 28, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association Guidelines Task ForceSamuel A Wells
Jun 9, 2009·Thyroid : Official Journal of the American Thyroid Association·Douglas W Ball
Jul 9, 2009·Thyroid : Official Journal of the American Thyroid Association·Ernest L MazzaferriDavid L Steward
Jul 26, 2012·Thyroid : Official Journal of the American Thyroid Association·Davide GiordanoVerter Barbieri
May 28, 2013·Thyroid : Official Journal of the American Thyroid Association·Frauke BentzienF Michael Yakes
Feb 25, 2000·Current Opinion in Oncology·J Bi, B Lu
Oct 20, 2012·Current Opinion in Oncology·Henning Dralle, Andreas Machens
Dec 20, 2005·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Michiel W M van den Brekel, Jonas A Castelijns
Dec 21, 2004·Journal of Internal Medicine·A MachensH Dralle
Sep 23, 2006·Annals of Surgical Oncology·José G GuillemKenneth Offit
Jul 3, 2008·Annals of Surgical Oncology·Maya D LeggettSteve R Martinez
Sep 30, 2010·Annals of Surgical Oncology·Deepak T AbrahamMark Sywak
Nov 23, 2013·AJR. American Journal of Roentgenology·Dhakshinamoorthy GaneshanChusilp Charnsangavej
Mar 7, 2013·European Journal of Endocrinology·J A A MeijerJ A Smit
Jun 22, 2014·Current Problems in Cancer·Amir H Lebastchi, Glenda G Callender
Jun 21, 2011·Journal of Thyroid Research·Karen GómezCamilo Jiménez
Jun 22, 2014·Journal of Endocrinological Investigation·M PucciniP Buccianti
Jul 22, 2014·Otolaryngologic Clinics of North America·David W Schoppy, F Christopher Holsinger
Aug 18, 2012·World Journal of Surgical Oncology·Yong-Seok Kim, Woo-Chan Park

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