Patterns of Oral PrEP Adherence and HIV Risk Among Eastern African Women in HIV Serodiscordant Partnerships

AIDS and Behavior
Maria PyraPartners Demonstration Project Team

Abstract

Understanding how women use PrEP is important for developing successful implementation programs. We hypothesized there are distinct patterns of adherence, related to HIV risk and other factors. We identified patterns of PrEP adherence and HIV risk behavior over the first 6 months of PrEP use, using data from 233 HIV-uninfected women in high-risk serodiscordant couples in a demonstration project in Kenya & Uganda. We modeled PrEP adherence, assessed by daily electronic monitoring, and HIV risk behavior using group-based trajectory models. We tested baseline covariates and risk behavior group as predictors of adherence patterns. There were four distinct adherence patterns: high steady adherence (55% of population), moderate steady (29%), late declining (8%), and early declining (9%). No baseline characteristics significantly differed between adherence patterns. Adherence patterns differed in average weekly doses (6.7 vs 5.4 vs 4.1 vs 1.5, respectively). Two risk behavior groups were identified: steady HIV risk (78% of population) and declining (22%). Compared to women with declining HIV risk behavior, women with steady risk behavior were more likely to have high steady adherence (61% vs 35%) and less likely to have early (6% vs 1...Continue Reading

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Citations

May 20, 2020·Current HIV/AIDS Reports·Matthew A SpinelliMonica Gandhi
May 15, 2020·Nature Medicine·Elizabeth M Irungu, Jared M Baeten
Jan 12, 2020·AIDS and Behavior·Valentine WangaUNKNOWN Partners Demonstration Project Team
Apr 17, 2021·AIDS and Behavior·Alexandra C WillcoxR Scott McClelland
Oct 13, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Maria PyraJohn Schneider

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