Patterns of patient and healthcare provider viewpoints regarding participation in HIV cure-related clinical trials. Findings from a multicentre French survey using Q methodology (ANRS-APSEC)

PloS One
C ProtièreM Suzan-Monti

Abstract

Despite huge advances in the fight against HIV concerning diagnosis, clinical efficacy of antiretroviral treatments (ART), patient survival and quality of life, there is still no cure. Recent developments in HIV cure research have opened the way for clinical trials which could lead to a temporary or definitive end to ART. However, ethical questions exist about related trial-participation risks. The main goal of the ANRS-APSEC survey was, using Q-methodology, to investigate the viewpoints of people living with HIV (PLWH) and HIV healthcare providers (HHP) regarding motivations for and barriers to participation in HIV Cure-related clinical trials (HCRCT). Thirty-three statements were defined encompassing seven dimensions: treatment and follow-up; risks; benefits; patient-physician relationship; beliefs and attitudes; information; target population. Forty-one PLWH and 41 HHP from five French HIV services were asked to rank-order the statements. Five main viewpoints were elicited from "the most motivated" to "the most reluctant" vis-à-vis HCRCT participation. All placed importance on the wish to participate in HIV research. This result is in line with the HIV-specific culture of joint mobilization. For some viewpoints, the motivati...Continue Reading

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Citations

Oct 31, 2019·Journal of the International AIDS Society·Karine DubéPaul Gaist
Mar 6, 2021·Journal of Comparative Effectiveness Research·Saskia Hendriks, Steven D Pearson
Jun 23, 2021·BMC Medical Research Methodology·Kate ChurrucaJeffrey Braithwaite
Jul 2, 2021·BMC Medical Ethics·Karine DubéJeremy Sugarman

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Software Mentioned

PLWH
VP1
HCRCT
PQMethod

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