Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma

Gut
Elizabeth D ThompsonRonan J Kelly

Abstract

Recent data supports a significant role for immune checkpoint inhibitors in the treatment of solid tumours. Here, we evaluate gastric and gastro-oesophageal junction (G/GEJ) adenocarcinomas for their expression of programmed death-ligand 1 (PD-L1), infiltration by CD8+ T cells and the relationship of both factors to patient survival. Thirty-four resections of primary invasive G/GEJ were stained by immunohistochemistry for PD-L1 and CD8 and by DNA in situ hybridisation for Epstein-Barr virus (EBV). CD8+ T cell densities both within tumours and at the tumour-stromal interface were analysed using whole slide digital imaging. Patient survival was evaluated according to PD-L1 status and CD8 density. 12% of resections showed tumour cell membranous PD-L1 expression and 44% showed expression within the immune stroma. Two cases (6%) were EBV positive, with one showing membranous PD-L1 positivity. Increasing CD8+ densities both within tumours and immune stroma was associated with increasing percentage of tumour (p=0.027) and stromal (p=0.005) PD-L1 expression. Both tumour and immune stromal PD-L1 expression and high intratumoral or stromal CD8+ T cell density (>500/mm2) were associated with worse progression-free survival (PFS) and overa...Continue Reading

References

Apr 22, 1997·International Journal of Cancer. Journal International Du Cancer·Y MaeharaK Sugimachi
Jan 17, 2003·The New England Journal of Medicine·Lin ZhangGeorge Coukos
Dec 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·R Houston ThompsonEugene D Kwon
Apr 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuichiro OhigashiYoshiyuki Nakajima
Dec 24, 2005·The New England Journal of Medicine·Franck PagèsJérôme Galon
Jan 15, 2011·International Journal of Biological Sciences·Ju-gao ChenQiao Li
Mar 16, 2012·Nature Reviews. Cancer·Wolf Herman FridmanJérôme Galon
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Aug 30, 2013·Science Translational Medicine·Stefani SprangerThomas F Gajewski
Nov 13, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Vamsidhar VelchetiDavid L Rimm
Apr 10, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Janis M TaubeRobert A Anders
Aug 1, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
May 7, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Janis M TaubeSuzanne L Topalian
May 16, 2015·Cancer Research·Michele W L TengMark J Smyth
Jun 2, 2015·The New England Journal of Medicine·Dung T LeLuis A Diaz

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Citations

Mar 12, 2019·The International Journal of Biological Markers·Young San Ko, Jung-Soo Pyo
Mar 17, 2017·British Journal of Cancer·Yanjing SongLin Chen
Apr 16, 2016·Nature Reviews. Cancer·Suzanne L TopalianDrew M Pardoll
Dec 10, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ruri SaitoMasashi Fukayama
Apr 11, 2019·The American Journal of Surgical Pathology·Teresa S KimLaura H Tang
May 18, 2019·American Society of Clinical Oncology Educational Book·Ramon Andrade De MelloYelena Y Janjigian
May 28, 2019·Breast Cancer Research and Treatment·Xiao-Yang ChenPuay Hoon Tan
Aug 8, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Ronan J Kelly
Oct 17, 2019·Journal of Cancer Research and Clinical Oncology·Guang YangZai-Shun Jin
Mar 15, 2020·Journal of Leukocyte Biology·Maria Grazia RefoloRosalba D'Alessandro
May 3, 2019·Current Opinion in Gastroenterology·Ronan J Kelly
Jan 4, 2020·Virchows Archiv : an International Journal of Pathology·Xiao-Yang ChenPuay Hoon Tan
May 30, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Koji KonoKosaku Mimura
Jul 18, 2019·Annals of Surgical Oncology·Yoshiyuki SasakiMasayuki Sho
Aug 5, 2020·JCO Global Oncology·Abdul Rahman JaziehWalid E Khalbuss
Aug 23, 2016·World Journal of Gastroenterology : WJG·Hui-Ying MaChun-Min Liang
Jun 2, 2017·Nature Reviews. Disease Primers·Jaffer A AjaniShumei Song
Sep 12, 2017·Helicobacter·Silvia Molina-CastroChristine Varon
Jun 2, 2018·Journal of Immunology Research·Haiyan TaiCongjian Xu
Sep 3, 2018·Cellular and Molecular Life Sciences : CMLS·Margherita RattiNicola Valeri
Dec 24, 2018·International Journal of Molecular Sciences·David VránaJanusz Jankowski
Sep 14, 2019·Therapeutic Advances in Gastroenterology·Gagandeep Brar, Manish A Shah
Oct 24, 2019·Journal of Oncology·Giuseppe SchepisiUgo De Giorgi
Jan 29, 2020·Pathology Oncology Research : POR·Haifeng ZhuLei Shi

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