Patterns of pineal melatonin secretion in rabbits: diurnal variation of basal and pulsatile release

Neuroendocrinology
Y S ChanS F Pang

Abstract

The level and release pattern of plasma melatonin in the confluens sinuum of 28 sighted and 18 blinded (i.e. acute bilateral orbital enucleation) rabbits anesthetized with pentobarbital were studied. The animals had been adapted to a 12:12 h light-dark regime. Blood samples were collected from the cannulated confluens sinuum and/or the femoral artery at either 2- or 4-min intervals in both the light and dark phases. Plasma melatonin was determined by radioimmunoassay. In all rabbits studied, plasma melatonin in the confluens sinuum exhibited an episodic release pattern, with pulses superimposed on a basal level. At 4-min sampling intervals, the pulsatile release of melatonin in sighted rabbits were 3.8 peaks/h in the light phase; shorter sampling interval (2-min) revealed more frequent pulsatile release of melatonin (5.1 peaks/h). In sighted animals in the light phase, the level of melatonin in the plasma of confluens sinuum was 7-15 times higher than that obtained from the plasma collected at the same time from the peripheral artery where the level of melatonin also exhibited pulsatile pattern. In blinded animals, melatonin levels in terms of mean concentration, mean maximum level and mean minimum (or baseline) level obtained ...Continue Reading

Citations

Aug 1, 1991·Molecular and Cellular Endocrinology·R J Reiter
Apr 1, 1991·Domestic Animal Endocrinology·M K Griffith, J E Minton
Mar 1, 1992·Journal of Pineal Research·M A SheikheldinW M Palmer
Jun 7, 2014·Pharmacological Reports : PR·Agnieszka BienertEdmund Grześkowiak
May 6, 2017·The European Journal of Neuroscience·S G WangJ I Nagy
Nov 9, 2018·The European Journal of Neuroscience·Raúl Aguilar-Roblero, Gabriela González-Mariscal

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