Patterns of plasma levels of catechols in neurogenic orthostatic hypotension

Annals of Neurology
D S GoldsteinI J Kopin

Abstract

Patients with neurogenic orthostatic hypotension can have deficits in sympathetic neural function at any of several levels of the sympathetic neuraxis. We determined whether patterns of plasma levels of dopa, norepinephrine, dihydroxyphenylglycol, and dihydroxyphenylacetic acid would distinguish patients with orthostatic hypotension associated with multiple system atrophy, pure autonomic failure, or deficiency of dopamine-beta-hydroxylase. Plasma levels of catechols were normal in most patients with multiple system atrophy, consistent with relatively intact peripheral sympathetic neurons; in contrast, most patients with pure autonomic failure had decreased levels of all four catechols, consistent with degenerative loss of sympathetic nerve endings. Patients with deficiency of dopamine-beta-hydroxylase had increased levels of dopa and dihydroxyphenylacetic acid and markedly decreased levels of norepinephrine and dihydroxyphenylglycol, suggesting compensatory increases in sympathetic nerve activity in the absence of norepinephrine biosynthesis. Subgroups of patients with pure autonomic failure or multiple system atrophy had low levels of norepinephrine with normal levels of dopa, dihydroxyphenylglycol, and dihydroxyphenylacetic a...Continue Reading

References

Feb 10, 1977·The New England Journal of Medicine·M G ZieglerI J Kopin
Jul 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·R J PolinskyI J Kopin
Jan 24, 1987·Lancet·A J Man in 't VeldM A Schalekamp
Oct 1, 1988·Journal of Neurochemistry·G EisenhoferI J Kopin
Apr 1, 1987·The Journal of Clinical Endocrinology and Metabolism·D S GoldsteinI J Kopin
Sep 1, 1988·Journal of the Autonomic Nervous System·G EisenhoferI J Kopin
Jan 1, 1988·The Journal of Clinical Investigation·D S GoldsteinI J Kopin
Nov 26, 1987·The New England Journal of Medicine·I BiaggioniD Robertson
Jan 1, 1985·The American Journal of the Medical Sciences·O KuchelJ Genest
May 1, 1973·British Medical Bulletin·L L Iversen
Jan 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·G M GuindiJ K Payne
Jan 1, 1965·Journal of Neurochemistry·J GLOWINSKIJ AXELROD

❮ Previous
Next ❯

Citations

Feb 1, 1993·Annals of Neurology·S G KalerW A Gahl
Oct 1, 1995·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·F CostaI Biaggioni
Sep 1, 1991·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·I T MeredithG Eisenhofer
Apr 9, 1998·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·M WeiserF B Axelrod
Aug 1, 1996·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·F B AxelrodI J Kopin
Feb 1, 1996·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·D S GoldsteinM C Dalakas
Nov 1, 1993·Italian Journal of Neurological Sciences·E Ferrari
Nov 28, 2012·Journal of Neurology·Manuela MetzlerGregor K Wenning
Jan 25, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·David S GoldsteinRoy Freeman
Feb 16, 2006·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·David S Goldstein
Jul 14, 2010·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·David S Goldstein
Feb 3, 2005·Current Hypertension Reports·Jens Jordan
Jul 1, 1992·Acta Astronautica·D RobertsonR M Robertson
Jun 11, 1991·Journal of the Autonomic Nervous System·D S GoldsteinG Eisenhofer
Mar 2, 1995·Journal of the Autonomic Nervous System·R FurlanA Malliani
Nov 1, 1996·The Journal of Laboratory and Clinical Medicine·T YamamotoI J Kopin
Jul 20, 2002·Journal of the Neurological Sciences·Samir M ParikhDavid Robertson
Apr 1, 1993·Baillière's Clinical Endocrinology and Metabolism·C J Mathias
Oct 24, 2003·Lancet Neurology·David S Goldstein
Jan 7, 2004·American Family Physician·John G Bradley, Kathy A Davis
Mar 6, 1997·The New England Journal of Medicine·D S GoldsteinI J Kopin
Jul 24, 1997·The New England Journal of Medicine·I J SchatzR J Polinsky
Mar 28, 2012·Brain : a Journal of Neurology·David S GoldsteinYehonatan Sharabi
Apr 3, 2002·The Journal of Clinical Hypertension·Jens Jordan, Italo Biaggioni
Dec 29, 1995·Annals of the New York Academy of Sciences·D S Goldstein
Apr 4, 2012·Hypertension·Cyndya ShibaoItalo Biaggioni
Jul 26, 2011·The Journal of Clinical Investigation·David S GoldsteinYehonatan Sharabi
Apr 15, 2014·Vascular Health and Risk Management·Stuart H Isaacson, Julia Skettini
Jul 9, 2004·Annals of the New York Academy of Sciences·David S Goldstein
Apr 29, 2003·Pacing and Clinical Electrophysiology : PACE·Blair P GrubbYousuf Kanjwal
Jul 29, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Yehonatan SharabiDavid S Goldstein
Jan 12, 2007·Cardiovascular Drug Reviews·David S Goldstein
Dec 12, 2012·Journal of Internal Medicine·A Fedorowski, O Melander
Nov 1, 1996·The Journal of Laboratory and Clinical Medicine·J R Shannon, D Robertson
Sep 4, 1998·The American Journal of Medicine·J JordanD Robertson
Feb 9, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Roy Freeman
Jun 15, 2011·Pharmacology & Therapeutics·Cyndya ShibaoItalo Biaggioni
May 20, 2015·Neurobiology of Disease·Brice LaurensWassilios G Meissner
Mar 12, 2015·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Jens JordanItalo Biaggioni
Jul 2, 2003·Diabetes Care·Giris JacobItalo Biaggioni
Jun 25, 2016·Current Neurology and Neuroscience Reports·Pariwat Thaisetthawatkul
Sep 14, 2016·Journal of the American Society of Hypertension : JASH·Horacio KaufmannWilliam B White

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.