Patterns of recurrence after low-dose-rate prostate brachytherapy: a population-based study of 2223 consecutive low- and intermediate-risk patients

International Journal of Radiation Oncology, Biology, Physics
Andrea C LoScott Tyldesley

Abstract

This study examined patterns of recurrence after low-dose-rate prostate brachytherapy (LDR-PB), estimated local recurrence rate and compared that rate to the estimated local recurrence rate after radical prostatectomy (RP). A prospective database was maintained with clinical, dosimetric, and outcome data for all LDR-PB implantation procedures performed at our institution. From 1998 to 2008, 2223 patients with prostate cancer received LDR-PB without supplemental external beam radiation therapy. Patients who developed Phoenix-defined biochemical failure were reviewed for sites of relapse and investigations completed. At a median follow-up of 5 years, 108 of 2223 patients (4.8%) developed biochemical relapse. In 1 additional patient, local relapse was found on transurethral prostate resection, but his prostate-specific antigen concentration was well short of triggering Phoenix-defined failure. Of the 109 patients with disease relapse, 18 of 2223 (0.8%) had a proven local recurrence, and 30 of 2223 (1.3%) had a proven distant recurrence. The remaining 61 of 2223 patients (2.7%) had unidentified sites of recurrence; of these, 57 patients (93%) had digital rectal examinations (DREs), 18 (30%) had post-treatment biopsies, 45 (74%) had...Continue Reading

References

Aug 16, 2005·Lancet·Michel BollaUNKNOWN European Organization for Research and Treatment of Cancer
Nov 7, 2006·International Journal of Radiation Oncology, Biology, Physics·Michael J ZelefskyEric M Horwitz
Nov 28, 2008·International Journal of Radiation Oncology, Biology, Physics·W James MorrisRyan Woods
Jun 23, 2009·International Journal of Radiation Oncology, Biology, Physics·Karel A HinnenMarco van Vulpen
Feb 6, 2010·International Journal of Radiation Oncology, Biology, Physics·Anna ThompsonW James Morris
Aug 3, 2010·International Journal of Radiation Oncology, Biology, Physics·Juanita CrookClement Ma
Apr 19, 2012·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Scott TyldesleyTom Pickles
Aug 21, 2013·Brachytherapy·W James MorrisIngrid Spadinger
Dec 18, 2013·International Journal of Radiation Oncology, Biology, Physics·Andrea C LoIngrid Spadinger
Aug 2, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·David S LambPeter B Bethwaite

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Citations

Nov 8, 2020·Brachytherapy·David S LambLisa Woods

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