Patterns of recurrence following liver resection for colorectal metastases: effect of primary rectal tumor site.

Archives of Surgery
Lia AssumpcaoTimothy M Pawlik

Abstract

Patients with rectal adenocarcinoma are at increased risk of locoregional recurrence compared with patients with colon cancer. This may affect the pattern of recurrence and survival rates following hepatic resection of liver metastases from rectal adenocarcinoma. Retrospective review of a prospectively collected cancer center database. From April 1, 1984, to December 31, 2005, 582 patients with liver metastases from a primary colorectal adenocarcinoma underwent hepatic resection. Clinical and pathological factors were analyzed using Cox regression analyses and log-rank tests. Of 582 patients, 141 (24.2%) had liver metastases from a primary rectal tumor site. Treatment of the primary rectal tumor most frequently included chemoradiation therapy (59.6%) and low anterior resection (63.1%). Most rectal tumors were pathological stage T3/T4 (85.8%) and N1 (68.1%). Treatment directed at the hepatic metastases included resection only (81.5%), resection plus radiofrequency ablation (17.8%), or radiofrequency ablation only (0.7%). With a median follow-up time of 30.7 months, 80 of 141 patients (56.7%) developed recurrence; 23 patients (16.3%) developed recurrence in the pelvis. Of 23 patients with pelvic recurrence, 56.5% also developed r...Continue Reading

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Citations

Aug 27, 2014·Journal of the American College of Surgeons·Gaya SpolveratoTimothy M Pawlik
Oct 4, 2012·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Thian Yee LiangBertrand W L Ang
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Jan 25, 2011·Journal of Surgical Oncology·Salvatore GruttadauriaBruno Gridelli
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