Patterns of regional cerebral blood flow associated with low hemoglobin in the Baltimore Longitudinal Study of Aging.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Rebecca F GottesmanSusan M Resnick

Abstract

Anemia has been associated with elevated cerebral blood flow (CBF) in animal models and certain clinical conditions (eg, renal disease), but whether hemoglobin level variations across a relatively normal range are associated with local or diffuse CBF changes is unclear. We investigated whether lower hemoglobin is associated with regional increases in relative CBF in older individuals, and if these increases occur in watershed regions. Seventy-four older nondemented adults underwent serial (15)O water positron emission tomography scans. Voxel-based analysis was used to investigate regional relative CBF patterns in association with hemoglobin level and in individuals with and without anemia. Analyses of cross-sectional relations between regional CBF and anemia were performed separately at two time points, 2 years apart, to identify replicable patterns of associations. Restricting results to associations replicated across two cross-sectional analyses, lower hemoglobin was associated with higher relative CBF within the middle/inferior frontal, occipital, precuneus, and cerebellar regions. In addition, individuals with anemia (n = 15) showed higher relative CBF in superior frontal, middle temporal, hippocampal, and gyrus rectus regi...Continue Reading

References

Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S VorstrupO B Paulson
Mar 1, 1992·Stroke; a Journal of Cerebral Circulation·A HinoH Tenjin
Aug 13, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A BuckV Pavlicek
Oct 1, 1998·Journal of Computer Assisted Tomography·A F GoldszalS M Resnick
May 18, 1999·JAMA : the Journal of the American Medical Association·G J IzaksD L Knook
Jul 3, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J MühlingG Hempelmann
Aug 19, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H ItoI Kanno
Dec 12, 2003·The Annals of Thoracic Surgery·Thomas F FloydJohn A Detre
Jul 22, 2004·Neurological Research·Gustavo C Román
Aug 5, 2005·Journal of the American Geriatrics Society·William B ErshlerDan L Longo
Oct 7, 2006·Current Opinion in Anaesthesiology·Gregory M T Hare
Jun 13, 2009·Critical Care : the Official Journal of the Critical Care Forum·Andreas H Kramer, David A Zygun
Aug 1, 2009·Stroke; a Journal of Cerebral Circulation·Carrington Rice WendellShari R Waldstein
Aug 18, 2009·Journal of the American Geriatrics Society·Jennifer A DealPaulo H M Chaves
Feb 18, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Masanobu IbarakiToshibumi Kinoshita
Feb 18, 2011·Acta Physiologica·M PaganiF Lind

❮ Previous
Next ❯

Citations

Jan 8, 2014·The Journal of Physiology·Christopher K WilliePhilip N Ainslie
Sep 13, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Andrea L C SchneiderRebecca F Gottesman
Jan 27, 2015·Neurobiology of Aging·Pieternella H van der VeenUNKNOWN SMART Study Group
May 31, 2016·Acta Psychiatrica Scandinavica·H VulserC Lemogne
Jun 1, 2016·Geriatrics & Gerontology International·Zhiyuan ShenZhongquan Sun
Jul 13, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yu-Chin SuShinn-Kuang Lin
Apr 11, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patricia ClementEric Achten
Apr 15, 2014·Annals of Clinical and Translational Neurology·Duygu TosunUNKNOWN the Alzheimer’s Disease Neuroimaging Initiative
Nov 22, 2019·Annals of Clinical and Translational Neurology·Jan SchönbergerJulia Jacobs
Oct 24, 2019·Journal of Alzheimer's Disease : JAD·Hong-Bae KimJae-Yong Shim
May 19, 2020·Clinical and Experimental Hypertension : CHE·Noushin YazdaniSaeid Taheri
Jul 9, 2020·European Stroke Journal·Valerian L AltersbergerUNKNOWN Thrombolysis in Stroke Patients (TRISP) collaborators
Mar 23, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lenis P Chen-EdinboroAdam P Spira
Mar 17, 2021·Chinese Medical Journal·Samantha N NeumannXiang Gao
Jun 8, 2018·Journal of Neuroscience Methods·Adam L UrbackBenjamin I Goldstein
Mar 5, 2021·The Journal of Nervous and Mental Disease·Jian-Hua ChengJin-Cai He
Jul 31, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lori L Beason-HeldSusan M Resnick

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.