Patterns of relapse and modalities of treatment of breast cancer: the 'IRIS' Project, a multicenter observational study

Oncology
M CazzanigaV Torri

Abstract

The aim of this study was to describe the patterns of breast cancer relapse and the factors influencing therapeutic choices in an unselected postmenopausal population. Five hundred and thirty-nine patients were enrolled between October 1999 and March 2001. The majority (92.6%) underwent surgery for the primary tumor: there was no difference between general and university hospitals in terms of the type of mastectomy, but a slight difference was found between Southern and Northern Centers. At the time of first relapse, 61.6% of the patients had a good Karnofsky performance status. The median disease-free interval (DFI) was 34 months. More than half of the patients (62.3%) presented a single metastasis. Metastatic disease was treated with chemotherapy in 64.8% of cases (alone in 44.1%, and in combination with hormone therapy in 20.1%), hormone therapy alone was given in 30.8% of cases. The main reasons for choosing chemotherapy were age (31%), standard guidelines (19.4%) and the site of metastatic disease (14.3%), and those for selecting hormone therapy were age (26.6%), site of relapse (19.3%), standard guidelines (19.2%), biological tumor characteristics (14.3%) and the DFI (11.1%). Taxane-containing treatments accounted for 46....Continue Reading

Citations

Mar 25, 2009·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Judith Barrios, Robert Wieder
Oct 23, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R RizzoliUNKNOWN International Osteoporosis Foundation Committee of Scientific Advisors Working Group on Cancer-Induced Bone Disease
Dec 16, 2004·British Journal of Cancer·A JimenoR Colomer

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