PMID: 11313092Apr 21, 2001Paper

Patterns of response to repeated total sleep deprivations in depression

Journal of Affective Disorders
M WiegandW Schreiber

Abstract

Patterns of response and nonresponse in repeated sleep deprivation (SD) are of both clinical and scientific interest; as yet, studies have yielded inconsistent results. Eighteen inpatients suffering from a major depression were subjected to a series of six scheduled total sleep deprivations within 3 weeks; 12 of them completed the whole protocol. All were under a constant antidepressant medication with amitriptyline. SD effects were measured using observer and self rating scales. Each single SD led to a significant improvement. Of the 12 patients who completed the protocol, seven were classified as responders at endpoint (i.e., 1 week after the sixth TSD). The majority of patients exhibited a pattern of responses and nonresponses randomly distributed over time. There was no temporal trend. The initial effect did not predict the average response to the following SDs. One third of patients dropped out before completing the protocol which limits the scope of the study. Response to a single SD is not generalizable on a series of following SDs in an individual. The mechanism of action of SD does probably not involve mechanisms subjected to habituation or sensitization.

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Citations

Dec 16, 2003·Journal of Affective Disorders·Henner Giedke
Aug 4, 2011·Neuropsychobiology·Francesco Benedetti, Cristina Colombo
Aug 12, 2009·Journal of Affective Disorders·Arun V RavindranUNKNOWN Canadian Network for Mood and Anxiety Treatments (CANMAT)
Jul 25, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael BauerUNKNOWN World Federation of Societies of Biological Psychiatry. Task Force on Unipolar Depressive Disorders
Mar 13, 2014·Medical Hypotheses·Jakob Korf
Jun 19, 2013·Journal of Affective Disorders·Arun V Ravindran, Tricia L da Silva
Apr 25, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael BauerUNKNOWN WFSBP Task Force on Unipolar Depressive Disorders
Dec 14, 2002·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael BauerUNKNOWN World Federation of Societies Biological Psychiatry Task Force on Treatment Guidelines for Unipolar Depressive Disorders

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