Patterns of retrograde axonal degeneration in the visual system

Brain : a Journal of Neurology
Willemien A de Vries-KnoppertAxel Petzold

Abstract

Conclusive evidence for existence of acquired retrograde axonal degeneration that is truly trans-synaptic (RTD) has not yet been provided for the human visual system. Convincing data rely on experimental data of lesions to the posterior visual pathways. This study aimed to overcome the limitations of previous human studies, namely pathology to the anterior visual pathways and neurodegenerative co-morbidity. In this prospective, longitudinal cohort retinal optical coherence tomography scans were acquired before and after elective partial temporal lobe resection in 25 patients for intractable epilepsy. Newly developed region of interest-specific, retinotopic areas substantially improved on conventional reported early treatment diabetic retinopathy study (ETDRS) grid-based optical coherence tomography data. Significant inner retinal layer atrophy separated patients with normal visual fields from those who developed a visual field defect. Acquired RTD affected the retinal nerve fibre layer, ganglion cell and inner plexiform layer and stopped at the level of the inner nuclear layer. There were significant correlations between the resected brain tissue volume and the ganglion cell layer region of interest (R = -0.78, P < 0.0001) and ...Continue Reading

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Citations

Dec 1, 2020·Brain : a Journal of Neurology·Axel PetzoldUNKNOWN UK Biobank Eye and Vision Consortium
Apr 16, 2021·Frontiers in Human Neuroscience·Shereif HaykalFrans W Cornelissen
May 20, 2021·Annals of Clinical and Translational Neurology·Axel PetzoldUNKNOWN IMSVISUAL, ERN-EYE Consortium
Aug 21, 2021·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Axel Petzold
Sep 7, 2021·Brain and Behavior·Avan Sabir RashidYumin Huang-Link

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