Patterns of serum type 1 and type 2 immune markers in healthy carriers of HTLV-I

Journal of Medical Virology
Brenda M BirmannSherri O Stuver

Abstract

Type 1 immunity appears to be diminished in healthy Japanese carriers of human T-lymphotropic virus type I (HTLV-I), but type 2 status remains undetermined. To further examine the subclinical effect of HTLV-I on host immunity, we measured serum antibodies to the Epstein-Barr virus (EBV) in 415 healthy Japanese adults to broadly characterize type 1 status. Levels of the type 2 biomarkers total immunoglobulin E (IgE), soluble CD23 (sCD23), and soluble CD30 (sCD30) were assessed in 167, 142, and 135 of these subjects, respectively. We analyzed the association of HTLV-I with levels of each serum marker using linear and logistic regression. Altered EBV antibody profiles that are consistent with deficient type 1 immunity were more prevalent in HTLV-I carriers than non-carriers (odds ratio (OR) = 2.8, 95% confidence interval (CI) = 1.5-5.3). Carriers also had 45% lower total IgE levels (P = 0.04) than non-carriers. In contrast, HTLV-I infection was not significantly associated with elevated levels of sCD23 or sCD30. These observations are contrary to our expectation of elevated type 2 biomarkers among carriers. We conclude that in this population, healthy carriers of HTLV-I may have subclinical deficiencies in both type 1 and type 2 i...Continue Reading

References

Jan 1, 1991·Advances in Immunology·G DelespesseA Dalloul
Aug 1, 1990·Clinical and Experimental Immunology·T MatsumotoJ Yodoi
May 15, 1990·International Journal of Cancer. Journal International Du Cancer·M PfreundschuhA Gause
Dec 15, 1988·International Journal of Cancer. Journal International Du Cancer·N TachibanaN Mueller
Sep 1, 1974·Human Pathology·W HenleC A Horwitz
Feb 15, 1983·International Journal of Cancer. Journal International Du Cancer·J Imai, Y Hinuma
Nov 1, 1994·Journal of Clinical Immunology·T L Whiteside
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E T LennetteG Klein
Jan 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·N MuellerN Tachibana
Jul 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B J Marsh
Oct 27, 1997·Clinical and Experimental Immunology·A BengtssonA Scheynius
Dec 2, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·M HisadaS Stuver
Aug 10, 2000·Clinical and Experimental Immunology·N KatohH Yasuno

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