Patterns of statin use and cholesterol goal attainment in a high-risk cardiovascular population: A retrospective study of primary care electronic medical records

Journal of Clinical Lipidology
Maria García-GilRafel Ramos

Abstract

To describe real-life patterns of statin use and cholesterol goal attainment in a retrospective cohort of patients with high cardiovascular risk. Retrospective cohort study of 21,636 individuals, 18.34% women, mean age 63.30 years (standard deviation 6.29). New statin users aged 35 to 74 years at high cardiovascular risk and with no previous cardiovascular disease in primary care electronic medical records (2006-2011). Patterns of statin use were based on statin type, potency, and 1-year statin switches. Relative mean reductions over 1 year and probability of goal attainment (<3.3 mmol/L). Natural patterns of statin use were identified using multiple correspondence analysis; general linear and logistic models were used to estimate low-density lipoprotein cholesterol (LDL-C) reductions and goal attainment probability. Three patterns of statin use were defined: low (3.82% of the population), moderate (71.94%), and high intensity (24.24%). After 1 year, potency decreased 42.74%, 64.16%, and 50.94%, respectively, and 37.41%, 29.47%, and 30.16% of the population stopped taking statins in low, moderate, and high patterns, respectively. Relative reductions in LDL-C: low intensity, 15.7% (95% confidence interval [CI]: -22.96 to 54.36);...Continue Reading

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Citations

May 20, 2017·International Journal of Clinical Pharmacy·Soubra LamaFattouh Youssef
Dec 10, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Jian-Jun LiQian Dong
Jan 18, 2018·BMC Geriatrics·Marina Guisado-ClaveroConcepción Violán
Jun 21, 2019·Journal of Clinical Medicine·Lia Alves-CabratosaRafel Ramos
Jun 15, 2019·BMC Family Practice·Marina Guisado-ClaveroQuintí Foguet-Boreu
May 26, 2021·Scientific Reports·Malihe AghasizadehToba Kazemi
Sep 15, 2021·Current Medical Research and Opinion·Vivencio BarriosAnastassia Anastassopoulou

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