Patterns of Tau and α-Synuclein Pathology in the Visual System

Journal of Parkinson's Disease
Jasmin RahimiGabor G Kovacs

Abstract

Spreading of misfolded proteins has been suggested for neurodegenerative diseases. The hierarchical distribution of protein deposits in Alzheimer's (AD) and Parkinson's disease (PD) supports this concept. To evaluate α-synuclein and tau-deposition in the optic pathway as an excellent anatomical model, which follows a strict trajectory including a cortico-geniculate feedback connection. We immunostained the optic nerve, lateral geniculate nucleus (LGN), and occipital cortex for AT8 (phosphorylated tau), α-synuclein, and disease-associated prion protein (PrP) in 47 cases with tau pathology (AD type, argyrophilic grain disease, or progressive supranuclear palsy), 16 PD, and 5 Creutzfeldt-Jakob disease (CJD) cases, respectively. We detected immunoreactivity for all proteins along the optic pathway. The optic nerve showed immunopositivity only in cases with tau (6/8, 75%) or α-synuclein (5/7, 71%) pathology. The LGN was involved also frequently (tau: 22/47, 46.8% ; α-synuclein: 15/16, 93.7% ; PrP 5/5, 100%). The occipital cortex was variably affected by tau or α-synuclein pathology, but always showed PrP immunoreactivity in the CJD cases. Tau pathology in the LGN correlated with tau immunoreactivity in the occipital cortex and Braak...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jul 1, 1989·Survey of Ophthalmology·B Katz, S Rimmer
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·A ErişirS M Sherman
Jul 27, 1999·Neuropathology and Applied Neurobiology·M Tolnay, A Probst
Jul 4, 2001·Journal of Neuroscience Research·A SurguchovI Surgucheva
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Apr 21, 2006·Journal of the Neurological Sciences·Ryoko YamamotoHeii Arai
Apr 9, 2008·Nature Medicine·Jeffrey H KordowerC Warren Olanow
Jun 9, 2009·Nature Cell Biology·Florence ClavagueraMarkus Tolnay
Aug 21, 2010·The Journal of Physiology·Farran Briggs, W Martin Usrey
Mar 26, 2011·Acta Neuropathologica·Gabor G KovacsHerbert Budka
Apr 26, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sibylle E Eisbach, Tiago F Outeiro
May 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Florence ClavagueraMarkus Tolnay
Jun 14, 2013·Journal of Glaucoma·Carlos Gustavo De Moraes
Nov 26, 2013·Journal of Parkinson's Disease·Pauline WalesTiago F Outeiro
Jan 8, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Ellen GelpiTeresa Ribalta
Feb 8, 2014·Nature Medicine·Jing L Guo, Virginia M Y Lee
Mar 15, 2014·Acta Neuropathologica Communications·Dominique BétempsThierry Baron
Mar 25, 2014·Acta Neuropathologica·Amanda N SacinoBenoit I Giasson
Apr 26, 2014·Brain : a Journal of Neurology·Nico J DiederichChristopher G Goetz
May 3, 2014·Neuroscience Letters·Thomas G BeachUNKNOWN Arizona Parkinson's Disease Consortium
May 13, 2014·Annals of Neurology·Ivan Bodis-WollnerShahnaz Miri
May 24, 2014·Neuron·Tara L Spires-Jones, Bradley T Hyman
Jun 6, 2014·BMC Neuroscience·Suzana AulićGiuseppe Legname
Aug 7, 2014·Acta Neuropathologica Communications·Masami Masuda-SuzukakeMasato Hasegawa
Nov 25, 2014·Alzheimer's Research & Therapy·Jasmin Rahimi, Gabor G Kovacs
Dec 17, 2014·Neuropathology and Applied Neurobiology·G G Kovacs

❮ Previous
Next ❯

Citations

Feb 6, 2016·International Journal of Molecular Sciences·Gabor G Kovacs
Feb 6, 2019·Acta Neuropathologica·Lien VeysLies De Groef
Feb 26, 2019·Annals of Neurology·Philip KreslGabor G Kovacs
Aug 10, 2019·Journal of Clinical Pathology·Gabor G Kovacs
Sep 23, 2019·Acta Neuropathologica·Eun-Joo KimWilliam W Seeley
Feb 8, 2020·Annals of Neurology·Elena MoroUNKNOWN Superior Colliculus Study Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes in Parkinson Disease

Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic neurons. Some PD-genes may be associated with astrocyte dysfunction. Discover the latest research on astrocytes in Parkinson's disease here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Bovine Spongiform Encephalopathy

Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Bovine Spongiform Encephalopathy (MDS)

Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.