Patterns of temperature adaptation in proteins from the bacteria Deinococcus radiodurans and Thermus thermophilus

Molecular Biology and Evolution
J H McDonald

Abstract

Asymmetrical patterns of amino acid substitution in proteins of organisms living at moderate and high temperatures (mesophiles and thermophiles, respectively) are generally taken to indicate selection favoring different amino acids at different temperatures due to their biochemical properties. If that were the case, comparisons of different pairs of mesophilic and thermophilic taxa would exhibit similar patterns of substitutional asymmetry. A previous comparison of mesophilic versus thermophilic Methanococcus with mesophilic versus thermophilic Bacillus revealed several pairs of amino acids for which one amino acid was favored in thermophilic Bacillus and the other was favored in thermophilic Methanococcus. Most of this could be explained by the higher G+C content of the DNA of thermophilic Bacillus, a phenomenon not seen in the Methanococcus comparison. Here, I compared the mesophilic bacterium Deinococcus radiodurans and its thermophilic relative Thermus thermophilus, which are similar in G+C content. Of the 190 pairs of amino acids, 83 exhibited significant substitutional asymmetry, consistent with the pervasive effects of selection. Most of these significantly asymmetrical pairs of amino acids were asymmetrical in the direc...Continue Reading

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Citations

Dec 15, 2010·Journal of Molecular Evolution·Richard W Jobson, Yin-Long Qiu
Dec 9, 2003·Journal of Molecular Biology·L MandrichG Manco
Jul 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jeremy L EnglandEugene I Shakhnovich
Jul 5, 2011·Doklady. Biochemistry and Biophysics·D A AfonnikovN A Kolchanov
Nov 5, 2013·Archaea : an International Microbiological Journal·Liudmila S YafremavaGustavo Caetano-Anollés
Apr 14, 2007·BMC Bioinformatics·K MizuguchiM V Cubellis
Oct 7, 2011·Proteins·Yunqi LiJianwen Fang
Jun 4, 2013·Journal of Theoretical Biology·Massimo Di Giulio
Apr 14, 2017·Scientific Reports·Krzysztof FiedorukIzabela Swiecicka
Aug 29, 2006·Molecular Biology and Evolution·Asher D CutterMark L Blaxter
Mar 13, 2020·Journal of Basic Microbiology·Li JinXiao-Xia Ma
Apr 11, 2020·Polymers·Daniel A Villamil Watson, David A Schiraldi

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