Patterns of Use of Induction Therapy for T2N0 Esophageal Cancer.

The Annals of Thoracic Surgery
Kristen E RhodinThomas A D'Amico

Abstract

Induction therapy for patients with cT2N0M0 esophageal cancer is controversial. We performed a retrospective cohort analysis of the National Cancer Database to examine the patterns of use of induction therapy for this population. The National Cancer Database was queried for patients with cT2N0M0 esophageal cancer who underwent esophagectomy (2004-2015). Patients were stratified by upfront surgery or induction therapy. Overall survival was analyzed and a multivariable logistic regression performed to identify factors associated with receipt of induction therapy. Overall 2540 patients met study criteria: 1177 (46%) received upfront esophagectomy and 1363 (53%) received induction therapy. Patients receiving induction therapy were more likely to be younger, male, without comorbidities, privately insured, and treated at a nonacademic center. These patients were also less likely to be treated in highest volume surgery centers. In multivariable regression, factors independently associated with receipt of induction therapy included later year of diagnosis, increasing tumor size, and increasing tumor grade. Factors associated with upfront esophagectomy included advancing age, comorbidities, lack of insurance, geographic location, and hi...Continue Reading

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Citations

Nov 20, 2020·The Annals of Thoracic Surgery·Wenjia WangYongbing Chen
Feb 24, 2021·The Annals of Thoracic Surgery·Kristen E RhodinThomas A D'Amico
Jun 19, 2021·Annals of Surgical Oncology·Giovanni CapovillaMichele Valmasoni

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