Abstract
Human immunodeficiency virus (HIV)-1 DNA and RNA levels and T lymphocyte cell surface markers were measured in blood serum and cell fractions from asymptomatic infected patients to find novel virologic and immunologic features in early disease predictive of subsequent clinical disease course. Thirty-two patients with rapid disease progression (rapid CD4+ cell loss and progression to clinical AIDS) were compared with 25 patients with stable infections (constant or rising CD4+ cell counts, no clinical disease manifestations). All HIV-1 burdens measured by polymerase chain reaction were consistently higher in specimens from rapid progressors than slow progressors. For each patient, virus burden remained relatively constant throughout the study period (mean, 42-44 months). Flow cytometry also disclosed stable lymphocyte immunophenotype patterns that correlated strongly with subsequent rapid progression to clinical disease. Thus, in early HIV-1 infection, a constellation of high virus burden and in vivo costimulatory antigen and lymphocyte activation abnormalities is predictive of rapid disease course.
Citations
Nov 14, 1998·Disease-a-month : DM·H W HorowitzG P Wormser
Nov 8, 2002·Mathematical Biosciences·James M HymanE Ann Stanley
Mar 6, 1999·Mathematical Biosciences·J M HymanE A Stanley
Feb 24, 2000·The Journal of Experimental Medicine·P J BlairC H June
Mar 9, 2000·AIDS·J B Hubert Rouzioux
Sep 21, 2000·AIDS·M PlanaJ M Gatell
Aug 15, 1997·The Journal of Clinical Investigation·M ComarM Giacca
Aug 1, 1997·Expert Opinion on Investigational Drugs·S J Best, E M Dax
Jan 8, 1999·Virology·S HodgeS Dewhurst
May 20, 1998·AIDS Research and Human Retroviruses·H MoJ P Moore
Feb 24, 1999·AIDS Research and Human Retroviruses·S P O'NeilE A Hoover
Apr 18, 2002·AIDS Research and Human Retroviruses·Jianming TangUNKNOWN REACH Study Group
Dec 15, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·C TortajadaJ M Gatell
May 10, 2006·Eukaryotic Cell·Sarah FranklandLeann Tilley
May 1, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Montserrat PlanaJosé M Gatell
Jan 23, 2020·Theoretical Biology & Medical Modelling·Xiaodan SunYanni Xiao
Apr 10, 1999·Journal of Virology·J R MascolaD L Birx
Jun 17, 1998·Journal of Virology·L WhetterS Dewhurst
Mar 14, 1998·Journal of Virology·A TrkolaJ P Moore
Aug 2, 2000·Journal of Clinical Microbiology·S Wünschmann, J T Stapleton
Sep 17, 1998·Journal of Clinical Microbiology·R SunJ Spadoro
Feb 18, 1998·Journal of Clinical Microbiology·K SebireC Birch