PMID: 9448205Feb 3, 1998Paper

Patterns of X chromosome inactivation in sporadic basal cell carcinomas: evidence for clonality

Journal of the American Academy of Dermatology
D S WalshH C Tsou

Abstract

Some basal cell carcinomas (BCCs) contain genetic mutations, suggesting that the lesion is composed of a monoclonal population of cells. Clonality, a distinguishing feature of neoplasia, can be inferred by referencing clonal markers such as the pattern of X chromosome inactivation. The X-linked human androgen receptor gene (HUMARA; GenBank) contains a polymorphic DNA marker that reliably illustrates the pattern of X chromosome inactivation in a tissue. Our purpose was to determine the clonality of sporadic BCCs by examining patterns of X chromosome inactivation. The patterns of X chromosome inactivation in paired samples of normal skin and sporadic BCCs from 24 women were compared by means of the HUMARA gene assay. All samples from normal skin displayed random X chromosome inactivation, consistent with lyonization. In 15 of 25 tumor samples (60%), nonrandom X chromosome inactivation was detected, consistent with monoclonality. At least some sporadic BCCs are composed of a monoclonal population of cells, strengthening the contention that a collection of mutations confers a growth advantage to this epithelial lesion.

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Citations

Aug 16, 2001·Trends in Endocrinology and Metabolism : TEM·A Levy
Dec 7, 2007·The Journal of Investigative Dermatology·Ellen Heitzer, Peter Wolf
Jan 10, 2009·The Journal of Investigative Dermatology·Ellen HeitzerPeter Wolf
Sep 21, 2001·The Journal of Investigative Dermatology·K J AshtonL R Griffiths
Apr 13, 2000·International Journal of Experimental Pathology·S B GarciaN A Wright
Mar 20, 2002·Archives of Pathology & Laboratory Medicine·Vijaya ChaturvediBrian J Nickoloff

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Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.