Paucity of HIV DNA methylation in latently infected, resting CD4+ T cells from infected individuals receiving antiretroviral therapy.

Journal of Virology
Jana BlazkovaA S Fauci

Abstract

Maintenance of HIV latency in vitro has been linked to methylation of HIV DNA. However, examinations of the degree of methylation of HIV DNA in the latently infected, resting CD4(+) T cells of infected individuals receiving antiretroviral therapy have been limited. Here, we show that methylation of the HIV 5' long terminal repeat (LTR) in the latent viral reservoir of HIV-infected aviremic individuals receiving therapy is rare, suggesting that other mechanisms are likely involved in the persistence of viral latency.

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Citations

Mar 23, 2013·Trends in Microbiology·Kotaro ShirakawaEric Verdin
Jun 28, 2013·Retrovirology·Carine Van LintAlessandro Marcello
Jul 9, 2013·Retrovirology·Samantha J McDonnelBrian G Murphy
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Jun 6, 2013·PLoS Pathogens·Gregory M LairdRobert F Siliciano
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