PMID: 9541201Apr 16, 1998Paper

Pax genes and organogenesis: Pax9 meets tooth development

European Journal of Oral Sciences
H PetersR Balling

Abstract

Pax genes encode a family of transcription factors that play key roles during embryogenesis. They are required for the development of a variety of organs including the nervous and muscular system, skeleton, eye, ear, kidney, thymus, and pancreas. Whereas the developmental roles of many of the nine known Pax genes have been analyzed in great detail, a functional analysis of Pax9 has just begun. During mouse embryogenesis, Pax9 exhibits a highly specific expression pattern in derivatives of the foregut endoderm, somites, limb mesenchyme, midbrain, and the cephalic neural crest. In the mandibular arch mesenchyme, the expression of Pax9 marks the prospective sites of tooth development prior to any morphological signs of odontogenesis and is maintained in the developing tooth mesenchyme thereafter. To understand the function of Pax9 during mouse embryogenesis, we recently have created a null allele by gene targeting. Preliminary analyses show that Pax9 is essential for the formation of teeth, and we conclude that Pax9 is required for tooth development to proceed beyond the bud stage. Here, we briefly summarize our current knowledge about Pax genes and introduce Pax9 to the growing family of factors which are involved in tooth develo...Continue Reading

Citations

Mar 19, 2014·European Journal of Medical Genetics·John BondsRena D'Souza
Apr 6, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F LézotA Berdal
Jul 3, 2008·Oral and Maxillofacial Surgery·M BehrG Handel
Sep 1, 2015·Seminars in Cell & Developmental Biology·Vanessa R Paixão-CôrtesMaria Cátira Bortolini
Nov 2, 2007·International Journal of Cancer. Journal International Du Cancer·Alexander RoeschThomas Vogt
Nov 16, 2011·Annals of the New York Academy of Sciences·Irina V Grigorieva, Rajesh V Thakker
Feb 13, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Romel Sebastián Sánchez, Sara S Sánchez
Feb 22, 2005·Archives of Oral Biology·F PriamA Poliard
Mar 8, 2000·Mechanisms of Development·J Jernvall, I Thesleff
Feb 3, 2012·Archives of Oral Biology·Adrianna MostowskaPawel P Jagodzinski
Sep 11, 2014·Human Molecular Genetics·Sonia SaccoSaïd Bendahhou
Feb 14, 2009·PLoS Biology·Gareth J FraserJ Todd Streelman
Feb 8, 2011·PloS One·Vanessa R Paixão-CôrtesMaria Cátira Bortolini
May 12, 2009·Human Molecular Genetics·Ying WangHitesh Kapadia
Nov 8, 2011·Mutagenesis·Junxia ZhuShuguo Zheng
Apr 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tiago V PereiraMaria-Cátira Bortolini
May 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Gareth J FraserMoya M Smith
Aug 23, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Pamela C Yelick, Thomas F Schilling
Oct 18, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M Mina
Nov 24, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·K M WeissZ Zhao
Nov 2, 2007·Orthodontics & Craniofacial Research·H KapadiaR D'Souza
May 18, 1999·Journal of Dental Research·A S Tucker, P T Sharpe
Dec 24, 2004·Journal of Dental Research·M L KleinS Kreiborg
Feb 17, 2015·British Dental Journal·D S Gill, C S Barker
Jul 9, 2005·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Gerhard Schlosser
Mar 6, 2003·Microscopy Research and Technique·Han-Sung JungHee-Jin Kim
Dec 25, 2009·The Journal of Craniofacial Surgery·Gabriele MuesRena N D'Souza
Jul 27, 2007·Orthodontics & Craniofacial Research·H KapadiaR D'Souza
Nov 22, 2007·European Journal of Oral Sciences·Victòria Tallón-WaltonPekka Nieminen
May 7, 2008·Biomedical Materials·Chang Du, Janet Moradian-Oldak
Dec 6, 2002·Endocrine Reviews·Hua ChangMartin M Matzuk
May 3, 2006·The Journal of Biological Chemistry·Takuya OgawaRena N D'Souza
Oct 15, 2019·PLoS Genetics·Lulin HuangZhenglin Yang
Jun 6, 2003·European Journal of Oral Sciences·Adrianna MostowskaWieslaw H Trzeciak
Oct 5, 2016·Human Genetics·M PhanC E L Carels
May 19, 2018·Genes·Meredith A Williams, Ariadne Letra
Sep 17, 2003·European Journal of Oral Sciences·Adrianna MostowskaWieslaw H Trzeciak

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