PAX immunoreactivity identifies alveolar rhabdomyosarcoma

The American Journal of Surgical Pathology
Lisa M SullivanRobin D LeGallo

Abstract

PAX5 is a member of the paired box transcription factors involved in development and its expression has been well characterized among hematopoietic malignancies of B-cell lineage. Its expression has also been reported in a subset of neuroendocrine carcinomas, urothelial tumors, Merkel cell carcinoma, glioblastoma, and neuroblastoma cell lines. As such, we sought to assess it as a diagnostic marker in the evaluation of pediatric small round blue cell tumors. Tumors selected for evaluation included embryonal rhabdomyosarcoma (55 cases), alveolar rhabdomyosarcoma (ARMS) (51 cases), neuroblastoma (22 cases), Wilms tumor (18 cases), Ewing Family of Tumors (11 cases), lymphoblastic lymphoma (8 cases), hepatoblastoma (6 cases), and granulocytic sarcoma (3 cases) as either cores in a tissue microarray or whole mount sections. All cases were immunostained using an antibody directed toward PAX5 and immunoreactivity was scored semiquantitatively according to percentage of nuclear staining. As expected, all B-cell lymphoblastic lymphomas were strongly immunoreactive against PAX5. Additionally, all Wilms tumors showed staining of variable intensity, most intensely in the epithelial component. Of the rhabdomyosarcoma cases, 34 of 51 (67%) AR...Continue Reading

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Citations

Jul 28, 2010·Clinical Medicine & Research·Mohamed M DesoukiJohn Lazarchick
Feb 16, 2010·American Journal of Clinical Pathology·Daniel A MorgensternJohn Anderson
Nov 18, 2009·Annals of Diagnostic Pathology·Steven GustafsonCarlos E Bueso-Ramos
Dec 15, 2010·Histopathology·Cyril Fisher
Aug 18, 2018·The American Journal of Dermatopathology·Laura BiedermanAdam I Rubin
Jun 5, 2018·The American Journal of Surgical Pathology·Vickie Y JoJason L Hornick
Aug 16, 2016·The American Journal of Surgical Pathology·Gregory W CharvilleMatt van de Rijn
Oct 12, 2014·International Journal of Surgical Pathology·Jason B KernAmy S Duffield

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