PAX2 and PAX8: useful markers for metastatic effusions

Acta Cytologica
Lindsay WatersDonna Coffey

Abstract

It was the aim of this study to determine the utility of PAX2 and PAX8 in cytology effusions with metastatic tumor. PAX2 and PAX8 immunohistochemical staining was performed on cell blocks of 89 pleural, pericardial and peritoneal effusions with benign diagnoses (18 cases), or secondary to renal cell carcinoma (RCC; 9 cases), müllerian carcinoma (21 cases) or non-müllerian carcinoma (41 cases). PAX2 stained 0% (0/18) of controls, 100% (8/8) of RCCs, 35% (7/20) of müllerian carcinomas, and 2% (1/41) of non-müllerian carcinomas. PAX8 stained 6% (1/18) of control cases, 100% (9/9) of RCC cases, 100% (20/20) of müllerian carcinomas, and 5% (2/41) of non-müllerian carcinomas. PAX2 was 35% sensitive and 95% specific for müllerian carcinoma and 100% sensitive and 95% specific for RCC. PAX8 was 100% sensitive and 95% specific for müllerian carcinoma and 100% sensitive and 95% specific for RCC. PAX8 is more sensitive than PAX2 for metastatic effusions from müllerian carcinomas (100 vs. 35%), while also having a higher intensity of staining than PAX2. However, PAX2 and PAX8 are both highly sensitive and specific for RCCs. PAX2 and PAX8 are valuable diagnostic markers for metastatic müllerian carcinomas and RCCs in effusion cytology. PAX8 ...Continue Reading

Citations

Mar 5, 2016·Cytopathology : Official Journal of the British Society for Clinical Cytology·D DamianiP Vielh
Sep 28, 2015·Seminars in Cell & Developmental Biology·Richa SharmaMaxime Bouchard
Dec 10, 2015·The Clinical Respiratory Journal·Robert HienschOleg Epelbaum
Nov 16, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·Marianne EngelsPinar Firat
Aug 30, 2017·Oncology Reports·Junxue DongTianmin Xu
Mar 25, 2020·Advances in Anatomic Pathology·Andrew M Bellizzi
Mar 7, 2021·Diagnostic Cytopathology·Wadad S MneimnehClaire W Michael
Apr 25, 2019·Acta Cytologica·Gordon H YuKaren S Gustafson

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