PMID: 7546735Sep 1, 1995Paper

Pax3: a paired domain gene as a regulator in PNS myelination

Neuron
C KioussiP Gruss

Abstract

Pax3 RNA is expressed in neural crest when Schwann cell (SC) precursors migrate to the PNS. Pax3 RNA and SC markers were monitored in sciatic nerves of mice during development and nerve repair. An inverse correlation was observed between expression of Pax3 RNA and myelin basic protein (MBP). Inverse correlation was also observed in SC primary cultures. Treating cultures with forskolin, an adenylate cyclase agonist, repressed Pax3 RNA, GFAP, NGFR, N-CAM, and L1 and elevated MBP. Subsequent microinjection with Pax3 expression vector elevated Pax3 RNA, GFAP, NGFR, N-CAM, and L1 and repressed MBP. Thus, Pax3 is likely involved in the differentiation pathway to myelinating SCs. Pax3 repressed a 1.3 kb MBP promoter fragment in cotransfection assays, suggesting that it represses MBP transcription.

References

Jun 1, 1992·Trends in Biochemical Sciences·G M Edelman, F S Jones
Apr 1, 1992·The Journal of Cell Biology·G J SnipesE M Shooter
Jan 1, 1991·Glia·K R Jessen, R Mirsky
Sep 1, 1988·Neuron·G Lemke
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M TaniuchiE M Johnson
Jan 1, 1986·Annual Review of Neuroscience·R P BungeC F Eldridge
Apr 1, 1973·Virology·F L Graham, A J van der Eb
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·G ChalepakisP Gruss
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·G ChalepakisP Gruss
Apr 1, 1994·The Journal of Cell Biology·C Kioussi, P Gruss
Dec 1, 1993·Molecular and Cellular Biology·H Matsushima, E Bogenmann

❮ Previous
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Citations

Jul 22, 1998·Microscopy Research and Technique·M Jaegle, D Meijer
Jul 22, 1998·Microscopy Research and Technique·K R Jessen, R Mirsky
Jun 16, 1999·Journal of Neuroscience Research·S A KoblarP F Bartlett
Sep 5, 2002·Journal of Neuroscience Research·Mehreen HaiPragna I Patel
Sep 8, 2012·Journal of Clinical Immunology·André HeinenPatrick Küry
Mar 1, 1996·Trends in Genetics : TIG·C Kioussi, P Gruss
Jul 1, 1997·Trends in Genetics : TIG·D J Anderson
Apr 27, 2000·Mechanisms of Development·R N KelshJ S Eisen
Dec 1, 1996·Current Opinion in Cell Biology·T S Zorick, G Lemke
Feb 1, 1996·Current Opinion in Neurobiology·R Mirsky, K R Jessen
Sep 2, 2005·Nature Reviews. Neuroscience·Kristjan R Jessen, Rhona Mirsky
Sep 19, 2012·Genes & Development·Claire AndersonAnne-Gaëlle Borycki
May 25, 2012·Pigment Cell & Melanoma Research·Johanna Djian-ZaoucheGeneviève Aubin-Houzelstein
Aug 7, 1999·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·J RodgerP H Kay
Mar 8, 2007·Annual Review of Neuroscience·Zu-Lin ChenSidney Strickland
May 17, 2008·The Journal of Clinical Investigation·Meilin WuJonathan A Epstein
Mar 26, 2013·PloS One·Judith A Blake, Melanie R Ziman
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ci-Di ChenCarmela R Abraham
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·J KhanP S Meltzer
Nov 6, 1998·Brain Pathology·H WernerK A Nave
Aug 31, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A AstolfiC De Giovanni
Nov 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wendy RoebKaren C Arden
May 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yasuhiro ItoMichael Sendtner
Dec 11, 1999·Current Opinion in Neurology·A Schenone, G L Mancardi
Sep 21, 2011·Progress in Neurobiology·Jennifer A Thompson, Mel Ziman
Jan 29, 2010·The Journal of Investigative Dermatology·Shujie HeMichael R Eccles
Apr 30, 2015·Glia·Kelly R MonkCarla Taveggia
Sep 28, 2015·Seminars in Cell & Developmental Biology·Anne H Monsoro-Burq
Apr 1, 2005·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Mary R Loeken
Sep 15, 2006·Journal of Cellular Physiology·N W RufautO A M Wallace
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Judith A BlakeMelanie Ziman

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