PAX5-AUTS2: a recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia.

Leukemia Research
D DenkS Strehl

Abstract

PAX5 rearrangements resulting in the expression of fusion transcripts account for 2-3% of childhood B-cell precursor acute lymphoblastic leukemia. Most PAX5 fusions are rare and many of them have only been described in a couple of, or even only in single, cases. We have identified the third case with a PAX5-AUTS2 fusion, which results from unbalanced t(7;9)(q11.2;p13.2) rearrangements. Our findings substantiate that PAX5-AUTS2 is a recurrent fusion gene in pediatric B-cell precursor acute lymphoblastic leukemia, and we summarize the clinical characteristics of such patients.

Citations

Sep 7, 2013·Trends in Genetics : TIG·Nir Oksenberg, Nadav Ahituv
Feb 11, 2014·Molecular Cytogenetics·Dagmar DenkSabine Strehl
Mar 13, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Erin E ElyJacqueline R Batanian
Apr 14, 2016·Journal of Molecular Biology·Cecilia Perez-BorrajeroLawrence P McIntosh
Nov 28, 2014·Medical Oncology·Mohammad ShahjahaniNajmaldin Saki
Jun 27, 2015·British Journal of Haematology·Irina StasevichHelena Kempski
Jan 18, 2014·Molecular Cancer Research : MCR·Klaus FortscheggerSabine Strehl
Mar 17, 2021·Nature Reviews. Molecular Cell Biology·Andrea Piunti, Ali Shilatifard
Aug 25, 2021·Trends in Genetics : TIG·Simone TamburriDiego Pasini

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