Pax6: a multi-level regulator of ocular development

Progress in Retinal and Eye Research
Ohad ShahamRuth Ashery-Padan

Abstract

Eye development has been a paradigm for the study of organogenesis, from the demonstration of lens induction through epithelial tissue morphogenesis, to neuronal specification and differentiation. The transcription factor Pax6 has been shown to play a key role in each of these processes. Pax6 is required for initiation of developmental pathways, patterning of epithelial tissues, activation of tissue-specific genes and interaction with other regulatory pathways. Herein we examine the data accumulated over the last few decades from extensive analyses of biochemical modules and genetic manipulation of the Pax6 gene. Specifically, we describe the regulation of Pax6's expression pattern, the protein's DNA-binding properties, and its specific roles and mechanisms of action at all stages of lens and retinal development. Pax6 functions at multiple levels to integrate extracellular information and execute cell-intrinsic differentiation programs that culminate in the specification and differentiation of a distinct ocular lineage.

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Citations

Jan 10, 2013·Investigative Ophthalmology & Visual Science·Jeong-Hoon JooStephen P Sugrue
Mar 22, 2013·PLoS Genetics·Ohad ShahamRuth Ashery-Padan
Jun 19, 2014·International Journal of Molecular Medicine·Bo MengBin Li
Apr 20, 2014·BMC Biology·Agustin Luz-MadrigalKatia Del Rio-Tsonis
Jan 15, 2014·Progress in Retinal and Eye Research·Jenny R Lenkowski, Pamela A Raymond
Jun 5, 2014·Human Molecular Genetics·Xiaohe YanJochen Graw
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Jul 8, 2016·Development·Yotam Menuchin-LasowskiRuth Ashery-Padan

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