Pazopanib (GW786034) and cyclophosphamide in patients with platinum-resistant, recurrent, pre-treated ovarian cancer - Results of the PACOVAR-trial

Gynecologic Oncology
C DinkicJ Rom

Abstract

The prognosis is poor for patients with recurrent, platinum-resistant epithelial ovarian cancer (EOC). Evidence suggests that antiangiogenic treatment modalities could play a major role in EOC. A combined therapy consisting of the investigational oral antiangiogenic agent pazopanib and metronomic oral cyclophosphamide may offer a well-tolerable treatment option to patients with recurrent, previously treated EOC. This study was designed as a multicenter phase I trial evaluating the optimal dose as well as activity and tolerability of pazopanib with metronomic cyclophosphamide in the treatment of patients with recurrent, platinum-resistant, previously treated ovarian, peritoneal, or fallopian tube cancer. Here, 50mg cyclophosphamide were combined with 400 to 800mg pazopanib daily. Sixteen patients were treated; mean age was 66years. At dose levels (DL) I and II, one instance of dose-limiting toxicity (DLT) was seen in one of 6 patients. At DL III, two of four patients showed a DLT, leading to a maximum tolerated dose (MTD) of 600mg pazopanib daily. Median number of administered cycles was 6 (2-13), with three patients being treated for at least 13months. Median progression-free survival (PFS) and overall survival (OS) were 8.35mo...Continue Reading

Citations

Jun 14, 2018·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yi-Kun WangFei Li
Sep 25, 2019·Cancers·Periklis KatopodisEmmanouil Karteris
Apr 25, 2019·Journal of Oncology·Cem SimsekSuayib Yalcin
Jul 31, 2020·Signal Transduction and Targeted Therapy·Qiao WangXia Zhao
Nov 27, 2020·Experimental Animals·Baran AkagunduzHalis Suleyman
Jun 3, 2021·Cancers·Marina Elena CazzanigaMaria Grazia Cerrito
Aug 14, 2021·Advanced Drug Delivery Reviews·Victoria LaiJoshua C Doloff

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